PMID- 23333530
OWN - NLM
STAT- MEDLINE
DCOM- 20130930
LR  - 20130401
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 82
IP  - 5
DP  - 2013 May
TI  - T1 mapping for detection of left ventricular myocardial fibrosis in hypertrophic 
      cardiomyopathy: a preliminary study.
PG  - e225-31
LID - S0720-048X(12)00642-0 [pii]
LID - 10.1016/j.ejrad.2012.12.014 [doi]
AB  - PURPOSE: To investigate the diagnostic value of T1 mapping imaging of evaluating 
      fibrosis in patients with hypertrophic cardiomyopathy (HCM). MATERIALS AND 
      METHODS: 21 subjects with HCM and 18 healthy volunteers underwent conventional 
      late gadolinium enhancement (LGE) imaging and T1 mapping imaging. The region of 
      myocardium in HCM is divided into remote area of LGE, peri-LGE, LGE (halo-like 
      LGE and typical patchy LGE). These regions combined with normal volunteers' 
      myocardium were calculated by the reduced percent of T1 value (RPTV). RESULTS: 
      The RPTV in healthy volunteers was no significant comparing with that in the 
      remote area of LGE in HCM subjects (3.98 +/- 3.19 vs. 3.34 +/- 2.75, P>0.05). There 
      were significant statistical differences in pairwise among the remote area of 
      LGE, peri-LGE, halo-like LGE and typical patchy LGE in the RPTV (P<0.0001). ROC 
      curves indicated that the T1 mapping imaging has a greater area under the curve 
      comparing with that of traditional LGE imaging (0.975 +/- 0.07 vs. 0.753 +/- 0.26, 
      P<0.0001). CONCLUSIONS: HCM has a high prevalence of fibrosis and with varying 
      severity. T1 mapping imaging can be a useful method to evaluate the severity of 
      the fibrosis in HCM.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Lu, Minjie
AU  - Lu M
AD  - Department of Radiology, State Key Laboratory of Cardiovascular Disease, Fuwai 
      Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical 
      Sciences and Peking Union Medical College, Beijing, China.
FAU - Zhao, Shihua
AU  - Zhao S
FAU - Yin, Gang
AU  - Yin G
FAU - Jiang, Shiliang
AU  - Jiang S
FAU - Zhao, Tao
AU  - Zhao T
FAU - Chen, Xiuyu
AU  - Chen X
FAU - Tian, Liangxin
AU  - Tian L
FAU - Zhang, Yan
AU  - Zhang Y
FAU - Wei, Yunqing
AU  - Wei Y
FAU - Liu, Qiong
AU  - Liu Q
FAU - He, Zuoxiang
AU  - He Z
FAU - Xue, Hui
AU  - Xue H
FAU - An, Jing
AU  - An J
FAU - Shah, Saurabh
AU  - Shah S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130117
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Cardiomyopathy, Hypertrophic/*complications/*pathology
MH  - Endomyocardial Fibrosis/*etiology/*pathology
MH  - Female
MH  - Humans
MH  - Image Enhancement/methods
MH  - Image Interpretation, Computer-Assisted/*methods
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
EDAT- 2013/01/22 06:00
MHDA- 2013/10/01 06:00
CRDT- 2013/01/22 06:00
PHST- 2012/09/27 00:00 [received]
PHST- 2012/12/18 00:00 [revised]
PHST- 2012/12/21 00:00 [accepted]
PHST- 2013/01/22 06:00 [entrez]
PHST- 2013/01/22 06:00 [pubmed]
PHST- 2013/10/01 06:00 [medline]
AID - S0720-048X(12)00642-0 [pii]
AID - 10.1016/j.ejrad.2012.12.014 [doi]
PST - ppublish
SO  - Eur J Radiol. 2013 May;82(5):e225-31. doi: 10.1016/j.ejrad.2012.12.014. Epub 2013 
      Jan 17.