PMID- 23333681
OWN - NLM
STAT- MEDLINE
DCOM- 20130917
LR  - 20181202
IS  - 1873-5177 (Electronic)
IS  - 0091-3057 (Linking)
VI  - 104
DP  - 2013 Mar
TI  - Enhanced nicotine-seeking behavior following pre-exposure to repeated cocaine is 
      accompanied by changes in BDNF in the nucleus accumbens of rats.
PG  - 169-76
LID - S0091-3057(13)00011-7 [pii]
LID - 10.1016/j.pbb.2013.01.007 [doi]
AB  - We investigated the behavioral and molecular interactions between cocaine and 
      nicotine, through evaluating locomotor activity, nicotine intravenous 
      self-administration and gene expression. Locomotor sensitization was induced in 
      male Wistar rats by repeated cocaine (20 mg/kg; i.p.) or saline injections once a 
      day over 7 days. Three days after the last injection, rats were challenged with 
      either saline or cocaine (15 mg/kg; i.p.) and the locomotor activity was 
      measured. The very next day animals received either saline or nicotine (0.4 
      mg/kg; s.c.) and the locomotor cross-sensitization was tested. Animals were then 
      prepared with intrajugular catheters for nicotine self-administration. Nicotine 
      self-administration patterns were evaluated using fixed or progressive ratio 
      schedules of reinforcement and a 24-h unlimited access binge. Immediately after 
      the binge sessions animals were decapitated, the brains were removed and the 
      nucleus accumbens was dissected. The dynorphin (DYN), mu-opioid receptor (mu 
      opioid), neuropeptide Y (NPY), brain-derived neurotrophic factor (BDNF), 
      tropomyosin-related tyrosine kinase B receptor (TrkB) and corticotropin-releasing 
      factor receptor type 1 (CRF-R1) gene expression were measured by the reverse 
      transcription-polymerase chain reaction (RT-PCR). Pretreatment with cocaine 
      caused sensitization of cocaine motor response and locomotor cross-sensitization 
      with nicotine. In the self-administration experiments repeated cocaine 
      administration caused an increase in the nicotine break point and nicotine intake 
      during a 24 h binge session.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Leao, Rodrigo M
AU  - Leao RM
AD  - Laboratory of Pharmacology, School of Pharmaceutical Sciences, Univ. Estadual 
      Paulista UNESP, Rod. Araraquara-Jau Km 1, 14801-902, Araraquara, Sao Paulo, 
      Brazil.
FAU - Cruz, Fabio C
AU  - Cruz FC
FAU - Carneiro-de-Oliveira, Paulo E
AU  - Carneiro-de-Oliveira PE
FAU - Rossetto, Daniella B
AU  - Rossetto DB
FAU - Valentini, Sandro R
AU  - Valentini SR
FAU - Zanelli, Cleslei F
AU  - Zanelli CF
FAU - Planeta, Cleopatra S
AU  - Planeta CS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130117
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuropeptide Y)
RN  - 0 (Receptors, Corticotropin-Releasing Hormone)
RN  - 0 (Receptors, Opioid, mu)
RN  - 5CLY6W2H1M (CRF receptor type 1)
RN  - 6M3C89ZY6R (Nicotine)
RN  - 74913-18-1 (Dynorphins)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cocaine/*administration & dosage
MH  - Dynorphins/genetics
MH  - Gene Expression/drug effects
MH  - Male
MH  - Motor Activity/drug effects
MH  - Neuropeptide Y/genetics
MH  - Nicotine/administration & dosage
MH  - Nucleus Accumbens/*drug effects/*physiopathology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, trkB/genetics
MH  - Receptors, Corticotropin-Releasing Hormone/genetics
MH  - Receptors, Opioid, mu/genetics
MH  - Risk Factors
MH  - Self Administration
MH  - Tobacco Use Disorder/*etiology/genetics/*physiopathology
EDAT- 2013/01/22 06:00
MHDA- 2013/09/18 06:00
CRDT- 2013/01/22 06:00
PHST- 2012/08/13 00:00 [received]
PHST- 2012/12/26 00:00 [revised]
PHST- 2013/01/10 00:00 [accepted]
PHST- 2013/01/22 06:00 [entrez]
PHST- 2013/01/22 06:00 [pubmed]
PHST- 2013/09/18 06:00 [medline]
AID - S0091-3057(13)00011-7 [pii]
AID - 10.1016/j.pbb.2013.01.007 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2013 Mar;104:169-76. doi: 10.1016/j.pbb.2013.01.007. 
      Epub 2013 Jan 17.