PMID- 23333821
OWN - NLM
STAT- MEDLINE
DCOM- 20130405
LR  - 20130213
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 92
IP  - 4-5
DP  - 2013 Mar 12
TI  - BDNF serum concentrations in first psychotic episode drug-naive schizophrenic 
      patients: associations with personality and BDNF Val66Met polymorphism.
PG  - 305-10
LID - S0024-3205(13)00013-1 [pii]
LID - 10.1016/j.lfs.2013.01.008 [doi]
AB  - AIMS: To investigate the relationship among brain derived neurotrophic factor 
      (BDNF) serum concentrations, BDNF Val66Met polymorphism and personality profile 
      in drug-naive schizophrenic patients with first-episode psychosis (FEP) and 
      healthy participants. MAIN METHODS: This cross-sectional study included fifty FEP 
      patients and fifty healthy participants who served as controls. To study their 
      personality profile the standardized Greek version of the Alternative Five-Factor 
      Zuckerman-Kuhlman Personality Questionnaire (ZKPQ) was administered. Serum BDNF 
      levels were measured and genotyping of BDNF Val66Met polymorphism was performed 
      in patients and healthy subjects. KEY FINDINGS: FEP patients presented lower BDNF 
      serum concentrations (P=0.002) and higher scores in ZKPQ Neuroticism (P=0.001) 
      and Aggression-Hostility (P=0.002) scales while lower scores in the ZKPQ 
      Sociability scale (P<0.001) than healthy participants. Multivariate analysis 
      revealed that the odds of being assessed with FEP were 0.4 times lower in those 
      with higher BDNF values (P<0.001) and 1.8 times greater in those with higher 
      Neuroticism scores (P<0.001). There were no significant differences with respect 
      to the Val66Met polymorphism between patients and healthy participants. 
      SIGNIFICANCE: Reduced BDNF serum concentrations along with higher Neuroticism 
      scores might be associated with FEP. A complex interplay between BDNF serum 
      concentrations, personality traits, BDNF Val66Met polymorphism, and psychotic 
      symptomatology has been arisen but further investigation is needed to better 
      clarify the observed associations.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Sotiropoulou, Marianthi
AU  - Sotiropoulou M
AD  - Department of Pharmacology, Medical School, University of Ioannina, 45110 
      Ioannina, Greece.
FAU - Mantas, Christos
AU  - Mantas C
FAU - Bozidis, Petros
AU  - Bozidis P
FAU - Marselos, Marios
AU  - Marselos M
FAU - Mavreas, Venetsanos
AU  - Mavreas V
FAU - Hyphantis, Thomas
AU  - Hyphantis T
FAU - Antoniou, Katerina
AU  - Antoniou K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130115
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood/genetics
MH  - Cross-Sectional Studies
MH  - Female
MH  - Genetic Association Studies
MH  - Genotype
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Neuropsychological Tests
MH  - *Personality
MH  - Personality Assessment
MH  - *Polymorphism, Single Nucleotide
MH  - Psychotic Disorders/*blood/genetics/psychology
MH  - Schizophrenia/*blood/genetics
MH  - *Schizophrenic Psychology
MH  - Young Adult
EDAT- 2013/01/22 06:00
MHDA- 2013/04/06 06:00
CRDT- 2013/01/22 06:00
PHST- 2012/08/07 00:00 [received]
PHST- 2012/12/02 00:00 [revised]
PHST- 2013/01/04 00:00 [accepted]
PHST- 2013/01/22 06:00 [entrez]
PHST- 2013/01/22 06:00 [pubmed]
PHST- 2013/04/06 06:00 [medline]
AID - S0024-3205(13)00013-1 [pii]
AID - 10.1016/j.lfs.2013.01.008 [doi]
PST - ppublish
SO  - Life Sci. 2013 Mar 12;92(4-5):305-10. doi: 10.1016/j.lfs.2013.01.008. Epub 2013 
      Jan 15.