PMID- 23334075
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20181202
IS  - 1537-162X (Electronic)
IS  - 0362-5664 (Linking)
VI  - 36
IP  - 1
DP  - 2013 Jan-Feb
TI  - Lamotrigine in binge-eating disorder associated with bipolar II depression and 
      treatment-resistant type 2 diabetes mellitus: a case report.
PG  - 34-5
LID - 10.1097/WNF.0b013e31827dbd3d [doi]
AB  - BACKGROUND: Lamotrigine (LMG) is an anticonvulsant currently registered for the 
      treatment of bipolar disorder (BP) depression. We report the case of a 
      61-year-old woman with comorbid binge-eating disorder (BED), BP depression, and 
      treatment-resistant type 2 diabetes mellitus (T2DM), in which LMG showed 
      significant efficacy against BED and BP depression and resulted in a drastic 
      decrease in plasma glucose levels. CASE REPORT: The patient had had untreated BP 
      depression, BED, and T2DM for more than 30 years. We prescribed LMG at 25 mg/d 
      for BP depression and titrated it up to 50 mg/d over 4 weeks, then maintained 
      this dose for the next 16 weeks. At follow-up after the first 4-week period, she 
      reported a significant decrease in compulsive eating impulses and depressive 
      mood, and her positive reports were consistent in the following months. 
      Hemoglobin A1c levels at National Glycohemoglobin Standardization Program 
      decreased drastically from 9.6% to 7.1% over the 20 weeks after initiating 
      treatment. CONCLUSION: This case suggests that LMG might be beneficial for BED 
      with concomitant BP depression, and potentially for treatment-resistant T2DM, if 
      this refractoriness is identified to result from comorbidity of BED and BP.
FAU - Yamamoto, Tetsuya
AU  - Yamamoto T
AD  - Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, 
      Japan. sangrecaliente54@gmail.com
FAU - Kanahara, Nobuhisa
AU  - Kanahara N
FAU - Hirai, Aizan
AU  - Hirai A
FAU - Watanabe, Hiroyuki
AU  - Watanabe H
FAU - Iyo, Masaomi
AU  - Iyo M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Clin Neuropharmacol
JT  - Clinical neuropharmacology
JID - 7607910
RN  - 0 (Antimanic Agents)
RN  - 0 (Blood Glucose)
RN  - 0 (Triazines)
RN  - U3H27498KS (Lamotrigine)
SB  - IM
MH  - Antimanic Agents/pharmacology/therapeutic use
MH  - Binge-Eating Disorder/blood/complications/*drug therapy
MH  - Bipolar Disorder/blood/complications/*drug therapy
MH  - Blood Glucose/drug effects/metabolism
MH  - Diabetes Mellitus, Type 2/blood/complications/*drug therapy
MH  - Female
MH  - Humans
MH  - Lamotrigine
MH  - Middle Aged
MH  - Triazines/pharmacology/*therapeutic use
EDAT- 2013/01/22 06:00
MHDA- 2013/10/18 06:00
CRDT- 2013/01/22 06:00
PHST- 2013/01/22 06:00 [entrez]
PHST- 2013/01/22 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - 00002826-201301000-00009 [pii]
AID - 10.1097/WNF.0b013e31827dbd3d [doi]
PST - ppublish
SO  - Clin Neuropharmacol. 2013 Jan-Feb;36(1):34-5. doi: 10.1097/WNF.0b013e31827dbd3d.