PMID- 23334242
OWN - NLM
STAT- MEDLINE
DCOM- 20150925
LR  - 20220408
IS  - 1436-3771 (Electronic)
IS  - 1432-6981 (Linking)
VI  - 17
IP  - 9
DP  - 2013 Dec
TI  - High HIF-1alpha expression genotypes in oral lichen planus.
PG  - 2011-5
LID - 10.1007/s00784-013-0920-8 [doi]
AB  - OBJECTIVE: The aim of this study is to assess whether C1772T and G1790A 
      hypoxia-inducible factor-1 (HIF-1)alpha polymorphisms are associated with risk of 
      oral lichen planus (OLP). MATERIAL AND METHODS: Restriction fragment length 
      polymorphism analysis was used to investigate HIF-1alpha C1779T and G1790A 
      polymorphisms in 32 OLP and 88 individuals without OLP. RESULTS: The frequency of 
      the CC, TT, GA, and AA genotypes was higher in patients with OLP. Notably, 
      individuals carrying the C and A, and T and A haplotypes showed a significant 
      association OLP risk. CONCLUSIONS: Our study demonstrated that the C1772T and 
      G1790A polymorphisms of HIF-1alpha gene increased the risk of OLP. C1772T and G1790A 
      polymorphisms of HIF-1alpha gene had differing patterns of allelic imbalance in the 
      normal samples and subsequent chronic lesions. Further studies are necessary to 
      elucidate the HIF-1alpha pathway in OLP, which would facilitate the development of 
      novel therapeutic strategies for the prevention and treatment of OLP. CLINICAL 
      RELEVANCE: These results, in conjunction with previous studies, suggest that 
      HIF-1alpha may play important roles in the chronicity of oral mucosa lesions of OLP 
      patients. Taken together, we suggest that HIF-1alpha polymorphisms enhance its target 
      genes, thereby altering the microenvironment and supporting sequential release of 
      inflammatory mediators or cellular events in OLP. It appears unlikely that 
      inhibition of a single proinflammatory mediator will prove useful in clinical 
      practice, but several ways to reprogram mediators engaged in a wide array of 
      roles simultaneously are encouraging.
FAU - de Carvalho Fraga, Carlos Alberto
AU  - de Carvalho Fraga CA
AD  - Department of Dentistry, Universidade Estadual de Montes Claros, Montes Claros, 
      Brazil.
FAU - Alves, Lucas Rodrigues
AU  - Alves LR
FAU - Marques-Silva, Luciano
AU  - Marques-Silva L
FAU - de Sousa, Adriana Alkmim
AU  - de Sousa AA
FAU - Jorge, Antonio Sergio Barcala
AU  - Jorge AS
FAU - de Jesus, Sabrina Ferreira
AU  - de Jesus SF
FAU - Vilela, Daniel Nogueira
AU  - Vilela DN
FAU - Pinheiro, Ugo Borges
AU  - Pinheiro UB
FAU - Jones, Kimberly Marie
AU  - Jones KM
FAU - de Paula, Alfredo Mauricio Batista
AU  - de Paula AM
FAU - Guimaraes, Andre Luiz Sena
AU  - Guimaraes AL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130119
PL  - Germany
TA  - Clin Oral Investig
JT  - Clinical oral investigations
JID - 9707115
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
MH  - *Genotype
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*genetics
MH  - Lichen Planus, Oral/*genetics
EDAT- 2013/01/22 06:00
MHDA- 2015/09/26 06:00
CRDT- 2013/01/22 06:00
PHST- 2012/05/30 00:00 [received]
PHST- 2013/01/07 00:00 [accepted]
PHST- 2013/01/22 06:00 [entrez]
PHST- 2013/01/22 06:00 [pubmed]
PHST- 2015/09/26 06:00 [medline]
AID - 10.1007/s00784-013-0920-8 [doi]
PST - ppublish
SO  - Clin Oral Investig. 2013 Dec;17(9):2011-5. doi: 10.1007/s00784-013-0920-8. Epub 
      2013 Jan 19.