PMID- 23334704
OWN - NLM
STAT- MEDLINE
DCOM- 20131227
LR  - 20140626
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 35
IP  - 1
DP  - 2013
TI  - Hyperhomocysteinemic mice show cognitive impairment without features of 
      Alzheimer's disease phenotype.
PG  - 59-66
LID - 10.3233/JAD-122347 [doi]
AB  - Hyperhomocysteinemia (HHcy) is associated with cognitive impairment and 
      Alzheimer's disease. Whether this association is mechanistic remains unclear. 
      Here, we used a mouse model to test the hypothesis that HHcy increases levels of 
      amyloid-beta (Abeta) transporters in microvessels that form the blood-brain barrier, 
      elevates Abeta content (Abeta40 and Abeta42) in the brain, and impairs cognitive 
      performance. Mice with HHcy and age-matched, non-HHcy controls (Ctrl) were 
      studied in two age groups: adult (6.2 +/- 0.4 months of age) and old (19 +/- 2.0 
      months of age). Levels of Abeta transporters, RAGE, LRP1, and Pgp, were not 
      different between HHcy and Ctrl mice. Though there was an increase in overall 
      brain Abeta levels with age, there were no differences between HHcy and Ctrl groups 
      in cortex, hippocampus, or midbrain/diencephalon. Despite the lack of difference 
      in Abeta, old mice with HHcy showed significant cognitive impairment on Morris water 
      maze tests compared with Ctrl mice. We conclude that HHcy leads to cognitive 
      impairment without many of the changes currently thought to be relevant to 
      promoting the AD phenotype.
FAU - Rhodehouse, Bryce C
AU  - Rhodehouse BC
AD  - Department of Biological Sciences, Idaho State University, Pocatello, ID 
      83209-8007, USA. bearshaw@isu.edu
FAU - Erickson, Michelle A
AU  - Erickson MA
FAU - Banks, William A
AU  - Banks WA
FAU - Bearden, Shawn E
AU  - Bearden SE
LA  - eng
GR  - 1R15HL106548/HL/NHLBI NIH HHS/United States
GR  - R01AG029839/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
SB  - IM
EIN - J Alzheimers Dis. 2013;35(4):877
MH  - *Alzheimer Disease/genetics/pathology
MH  - Animals
MH  - Cognition Disorders/*genetics/pathology
MH  - Female
MH  - Hyperhomocysteinemia/*genetics/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - *Phenotype
EDAT- 2013/01/22 06:00
MHDA- 2013/12/29 06:00
CRDT- 2013/01/22 06:00
PHST- 2013/01/22 06:00 [entrez]
PHST- 2013/01/22 06:00 [pubmed]
PHST- 2013/12/29 06:00 [medline]
AID - G875824M86G880H1 [pii]
AID - 10.3233/JAD-122347 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2013;35(1):59-66. doi: 10.3233/JAD-122347.