PMID- 23334931
OWN - NLM
STAT- MEDLINE
DCOM- 20140218
LR  - 20211021
IS  - 1874-9356 (Electronic)
IS  - 0015-5632 (Linking)
VI  - 58
IP  - 5
DP  - 2013 Sep
TI  - Candidate target genes for the Saccharomyces cerevisiae transcription factor, 
      Yap2.
PG  - 403-8
LID - 10.1007/s12223-013-0224-z [doi]
AB  - In Saccharomyces cerevisiae, the Yap family of basic leucine zipper (bZip) 
      proteins contains eight members. The Yap family proteins are implicated in a 
      variety of stress responses; among these proteins, Yap1 acts as a major regulator 
      of oxidative stress responses. However, the functional roles of the remaining Yap 
      family members are poorly understood. To elucidate the function of Yap2, we mined 
      candidate target genes of Yap2 by proteomic analysis. Among the identified genes, 
      FRM2 was previously identified as a target gene of Yap2, which confirmed the 
      validity of our screening method. YNL134C and YDL124W were also identified as 
      candidate Yap2 target genes. These genes were upregulated in strains 
      overexpressing Yap2 and possess Yap2 target sequences in their promoter regions. 
      Furthermore, chromatin immunoprecipitation assays showed that YNL134C and YDL124W 
      have Yap2 binding motif. These data will help to elucidate the functional role of 
      Yap2.
FAU - Bang, Seo Young
AU  - Bang SY
AD  - Medical Proteomics Research Center, KRIBB, Daejeon, 305-806, Republic of Korea.
FAU - Kim, Jeong Hoon
AU  - Kim JH
FAU - Lee, Phil Young
AU  - Lee PY
FAU - Chi, Seung-Wook
AU  - Chi SW
FAU - Cho, Sayeon
AU  - Cho S
FAU - Yi, Gwan-Su
AU  - Yi GS
FAU - Myung, Pyung Keun
AU  - Myung PK
FAU - Park, Byoung Chul
AU  - Park BC
FAU - Bae, Kwang-Hee
AU  - Bae KH
FAU - Park, Sung Goo
AU  - Park SG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130119
PL  - United States
TA  - Folia Microbiol (Praha)
JT  - Folia microbiologica
JID - 0376757
RN  - 0 (CAD1 protein, S cerevisiae)
RN  - 0 (DNA, Fungal)
RN  - 0 (Saccharomyces cerevisiae Proteins)
RN  - 0 (Transcription Factors)
RN  - EC 1.- (Oxidoreductases)
RN  - EC 1.- (YNL134C protein, S cerevisiae)
RN  - EC 1.1.- (Alcohol Oxidoreductases)
RN  - EC 1.1.1.- (YDL124W protein, S cerevisiae)
SB  - IM
MH  - Alcohol Oxidoreductases/*biosynthesis/genetics
MH  - Binding Sites
MH  - Chromatin Immunoprecipitation
MH  - DNA, Fungal/genetics
MH  - *Gene Expression Regulation, Fungal
MH  - *Genes, Fungal
MH  - Oxidoreductases/*biosynthesis/genetics
MH  - Promoter Regions, Genetic
MH  - Protein Binding
MH  - Proteomics/methods
MH  - Saccharomyces cerevisiae/*genetics/*metabolism
MH  - Saccharomyces cerevisiae Proteins/*biosynthesis/genetics/*metabolism
MH  - Transcription Factors/*metabolism
EDAT- 2013/01/22 06:00
MHDA- 2014/02/19 06:00
CRDT- 2013/01/22 06:00
PHST- 2012/07/01 00:00 [received]
PHST- 2013/01/09 00:00 [accepted]
PHST- 2013/01/22 06:00 [entrez]
PHST- 2013/01/22 06:00 [pubmed]
PHST- 2014/02/19 06:00 [medline]
AID - 10.1007/s12223-013-0224-z [doi]
PST - ppublish
SO  - Folia Microbiol (Praha). 2013 Sep;58(5):403-8. doi: 10.1007/s12223-013-0224-z. 
      Epub 2013 Jan 19.