PMID- 23335390
OWN - NLM
STAT- MEDLINE
DCOM- 20131108
LR  - 20211021
IS  - 1099-1492 (Electronic)
IS  - 0952-3480 (Print)
IS  - 0952-3480 (Linking)
VI  - 26
IP  - 6
DP  - 2013 Jun
TI  - Altered functional brain networks in Prader-Willi syndrome.
PG  - 622-9
LID - 10.1002/nbm.2900 [doi]
AB  - Prader-Willi syndrome (PWS) is a genetic imprinting disorder characterized mainly 
      by hyperphagia and early childhood obesity. Previous functional neuroimaging 
      studies used visual stimuli to examine abnormal activities in the eating-related 
      neural circuitry of patients with PWS. It was found that patients with PWS 
      exhibited both excessive hunger and hyperphagia consistently, even in situations 
      without any food stimulation. In the present study, we employed resting-state 
      functional MRI techniques to investigate abnormal brain networks related to 
      eating disorders in children with PWS. First, we applied amplitude of 
      low-frequency fluctuation analysis to define the regions of interest that showed 
      significant alterations in resting-state brain activity levels in patients 
      compared with their sibling control group. We then applied a functional 
      connectivity (FC) analysis to these regions of interest in order to characterize 
      interactions among the brain regions. Our results demonstrated that patients with 
      PWS showed decreased FC strength in the medial prefrontal cortex (MPFC)/inferior 
      parietal lobe (IPL), MPFC/precuneus, IPL/precuneus and IPL/hippocampus in the 
      default mode network; decreased FC strength in the pre-/postcentral gyri and 
      dorsolateral prefrontal cortex (DLPFC)/orbitofrontal cortex (OFC) in the motor 
      sensory network and prefrontal cortex network, respectively; and increased FC 
      strength in the anterior cingulate cortex/insula, ventrolateral prefrontal cortex 
      (VLPFC)/OFC and DLPFC/VLPFC in the core network and prefrontal cortex network, 
      respectively. These findings indicate that there are FC alterations among the 
      brain regions implicated in eating as well as rewarding, even during the resting 
      state, which may provide further evidence supporting the use of PWS as a model to 
      study obesity and to provide information on potential neural targets for the 
      medical treatment of overeating.
CI  - Copyright (c) 2013 John Wiley & Sons, Ltd.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Life Sciences Research Center, School of Life Sciences and Technology, Xidian 
      University, Xi'an, Shaanxi, China.
FAU - Zhao, Heng
AU  - Zhao H
FAU - Qiu, Siyou
AU  - Qiu S
FAU - Tian, Jie
AU  - Tian J
FAU - Wen, Xiaotong
AU  - Wen X
FAU - Miller, Jennifer L
AU  - Miller JL
FAU - von Deneen, Karen M
AU  - von Deneen KM
FAU - Zhou, Zhenyu
AU  - Zhou Z
FAU - Gold, Mark S
AU  - Gold MS
FAU - Liu, Yijun
AU  - Liu Y
LA  - eng
GR  - K23 DK081203/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20130121
PL  - England
TA  - NMR Biomed
JT  - NMR in biomedicine
JID - 8915233
SB  - IM
MH  - Adolescent
MH  - Brain/*physiopathology
MH  - Brain Mapping
MH  - Child
MH  - Child, Preschool
MH  - Feeding and Eating Disorders/*physiopathology
MH  - Female
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Nerve Net/*physiopathology
MH  - Parietal Lobe/physiopathology
MH  - Prader-Willi Syndrome/*physiopathology
MH  - Prefrontal Cortex/physiopathology
PMC - PMC3776442
MID - NIHMS511888
EDAT- 2013/01/22 06:00
MHDA- 2013/11/10 06:00
PMCR- 2014/06/01
CRDT- 2013/01/22 06:00
PHST- 2012/08/26 00:00 [received]
PHST- 2012/11/05 00:00 [revised]
PHST- 2012/11/06 00:00 [accepted]
PHST- 2013/01/22 06:00 [entrez]
PHST- 2013/01/22 06:00 [pubmed]
PHST- 2013/11/10 06:00 [medline]
PHST- 2014/06/01 00:00 [pmc-release]
AID - 10.1002/nbm.2900 [doi]
PST - ppublish
SO  - NMR Biomed. 2013 Jun;26(6):622-9. doi: 10.1002/nbm.2900. Epub 2013 Jan 21.