PMID- 23336931
OWN - NLM
STAT- MEDLINE
DCOM- 20131216
LR  - 20181202
IS  - 1743-1328 (Electronic)
IS  - 0161-6412 (Linking)
VI  - 35
IP  - 2
DP  - 2013 Mar
TI  - Combination benefit of amlodipine plus atorvastatin treatment on carotid 
      atherosclerosis in Zucker metabolic rats.
PG  - 181-6
LID - 10.1179/1743132812Y.0000000131 [doi]
AB  - OBJECTIVES: Obesity is the major risk factor for metabolic syndrome and 
      atherosclerotic cardiocerebrovascular diseases. METHODS: We studied effects of 
      amlodipine, atorvastatin, and their combination on carotid arteriosclerotic 
      processes in a metabolic syndrome model of Zucker fatty rats. Zucker fatty rats 
      were treated with vehicle, amlodipine, atorvastatin, or combination amlodipine 
      plus atorvastatin for 28 days. RESULTS: Compared with the single treatment with 
      amlodipine or atorvastatin, the combination of amlodipine plus atorvastatin 
      treatment prevented arteriosclerotic processes, and induced a strong recovery of 
      Sirtuin1 (Sirt1) expression and a marked reduction in p53, p21, and monocyte 
      chemoattractant protein-1 (MCP-1). DISCUSSION: As Sirt1 is a longevity gene that 
      prevents endothelial atherosclerotic processes, and p53, p21, and MCP-1 play 
      pivotal roles in the initiation and development of atherosclerosis, these data 
      suggest a strong synergistic benefit of combination therapy with amlodipine and 
      atorvastatin for preventing atherosclerotic processes, and potentially reducing 
      the clinical risk of cerebrovascular events in metabolic obesity patients.
FAU - Kawai, Hiromi
AU  - Kawai H
AD  - Depatment of Neurology, Okayama University Graduate School of Medicine, Dentistry 
      and Pharmaceutical Sciences, Okayama 700-8558, Japan.
FAU - Kurata, Tomoko
AU  - Kurata T
FAU - Deguchi, Kentaro
AU  - Deguchi K
FAU - Deguchi, Shoko
AU  - Deguchi S
FAU - Yamashita, Toru
AU  - Yamashita T
FAU - Ohta, Yasuyuki
AU  - Ohta Y
FAU - Omote, Yoshio
AU  - Omote Y
FAU - Kono, Syoichiro
AU  - Kono S
FAU - Abe, Koji
AU  - Abe K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20121217
PL  - England
TA  - Neurol Res
JT  - Neurological research
JID - 7905298
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p21)
RN  - 0 (Heptanoic Acids)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Pyrroles)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 1J444QC288 (Amlodipine)
RN  - A0JWA85V8F (Atorvastatin)
RN  - EC 3.5.1.- (Sirtuin 1)
SB  - IM
MH  - Amlodipine/*administration & dosage
MH  - Animals
MH  - Antihypertensive Agents/administration & dosage
MH  - Atorvastatin
MH  - Carotid Artery Diseases/*drug therapy/*metabolism
MH  - Carotid Artery, Common/*drug effects/metabolism
MH  - Chemokine CCL2/biosynthesis
MH  - Cyclin-Dependent Kinase Inhibitor p21/biosynthesis
MH  - Drug Therapy, Combination
MH  - Endothelial Cells/metabolism
MH  - Heptanoic Acids/*administration & dosage
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage
MH  - Male
MH  - Pyrroles/*administration & dosage
MH  - Rats
MH  - Sirtuin 1/biosynthesis
MH  - Tumor Suppressor Protein p53/biosynthesis
EDAT- 2013/01/23 06:00
MHDA- 2013/12/18 06:00
CRDT- 2013/01/23 06:00
PHST- 2013/01/23 06:00 [entrez]
PHST- 2013/01/23 06:00 [pubmed]
PHST- 2013/12/18 06:00 [medline]
AID - ner2827 [pii]
AID - 10.1179/1743132812Y.0000000131 [doi]
PST - ppublish
SO  - Neurol Res. 2013 Mar;35(2):181-6. doi: 10.1179/1743132812Y.0000000131. Epub 2012 
      Dec 17.