PMID- 23336975
OWN - NLM
STAT- MEDLINE
DCOM- 20150610
LR  - 20181202
IS  - 1865-1682 (Electronic)
IS  - 1865-1674 (Linking)
VI  - 61
IP  - 6
DP  - 2014 Dec
TI  - A Bayesian phylogeographical analysis of type 1 porcine reproductive and 
      respiratory syndrome virus (PRRSV).
PG  - 537-45
LID - 10.1111/tbed.12058 [doi]
AB  - Understanding viral transmission is an important factor for the effective 
      prevention one of the most devastating swine diseases, porcine reproductive and 
      respiratory syndrome. Focusing on molecular epidemiology of type 1 PRRSV, this 
      study analysed a large ORF5 dataset collected worldwide from 1991 to 2012 using a 
      coalescent-based Bayesian Markov chain Monte Carlo approach. The results 
      suggested that the virus diversified into unique subpopulations in Russia & 
      Belarus and Italy approximately 100 years ago. Previously unreported consecutive 
      diffusions of the virus were identified, which showed that some countries, such 
      as Spain and Germany, acted as distribution sources to some extent. This study 
      also provided statistical evidence for the existence of an ORF5-based 
      phylogeographical structure of type 1 PRRSV, in which the virus tended to cluster 
      by geographical locations more tightly than expected by chance. In contrast to 
      this tight geographical structure, the evolution of the ORF5 gene, based on 
      mapping of non-synonymous/synonymous substitutions, was best described by a 
      non-homogeneous process that could be implicated as a mechanism for viral immune 
      evasion.
CI  - (c) 2013 Blackwell Verlag GmbH.
FAU - Nguyen, V G
AU  - Nguyen VG
AD  - Department of Veterinary Medicine Virology Laboratory, College of Veterinary 
      Medicine and Research Institute for Veterinary Science, Seoul National 
      University, Seoul, Korea; Department of Microbiology and Infectious Diseases, 
      Faculty of Veterinary Medicine, Hanoi University of Agriculture, Hanoi, Vietnam.
FAU - Kim, H K
AU  - Kim HK
FAU - Moon, H J
AU  - Moon HJ
FAU - Park, S J
AU  - Park SJ
FAU - Chung, H C
AU  - Chung HC
FAU - Choi, M K
AU  - Choi MK
FAU - Park, B K
AU  - Park BK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130122
PL  - Germany
TA  - Transbound Emerg Dis
JT  - Transboundary and emerging diseases
JID - 101319538
RN  - 0 (Viral Envelope Proteins)
RN  - 0 (glycoprotein 5, PRRSV)
SB  - IM
MH  - Animals
MH  - Bayes Theorem
MH  - Europe/epidemiology
MH  - Molecular Epidemiology
MH  - Phylogeny
MH  - Phylogeography
MH  - Porcine Reproductive and Respiratory Syndrome/epidemiology/*virology
MH  - *Porcine respiratory and reproductive syndrome 
      virus/classification/genetics/isolation & purification
MH  - Swine
MH  - Viral Envelope Proteins/genetics
OTO - NOTNLM
OT  - Bayesian phylogeography
OT  - ORF5 gene
OT  - type 1 PRRSV
EDAT- 2013/01/23 06:00
MHDA- 2015/06/11 06:00
CRDT- 2013/01/23 06:00
PHST- 2012/10/29 00:00 [received]
PHST- 2013/01/23 06:00 [entrez]
PHST- 2013/01/23 06:00 [pubmed]
PHST- 2015/06/11 06:00 [medline]
AID - 10.1111/tbed.12058 [doi]
PST - ppublish
SO  - Transbound Emerg Dis. 2014 Dec;61(6):537-45. doi: 10.1111/tbed.12058. Epub 2013 
      Jan 22.