PMID- 23337034
OWN - NLM
STAT- MEDLINE
DCOM- 20131218
LR  - 20130513
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 44
DP  - 2013 Jul 1
TI  - Relationship between negative symptoms and plasma levels of insulin-like growth 
      factor 1 in first-episode schizophrenia and bipolar disorder patients.
PG  - 29-33
LID - S0278-5846(13)00010-9 [pii]
LID - 10.1016/j.pnpbp.2013.01.008 [doi]
AB  - Previous studies have suggested that insulin-like growth factor-1 (IGF-1) is 
      altered in schizophrenia. The objective of this study was to investigate whether 
      plasma IGF-1 levels were altered at the onset of psychiatric disorders such as 
      schizophrenia or bipolar disorder. We focused at the first psychotic episode 
      (FPE) and during 1-year follow-up. We also studied if IGF-1 levels were related 
      to clinical symptoms. 50 patients and 43 healthy controls matched by age, gender 
      and educational level were selected from the Basque Country catchment area in 
      Spain. Plasma IGF-1 levels were measured at FPE and 1 month, 6 months and one 
      year later. Patient symptoms were assessed at the same disease stages using the 
      Positive and Negative Symptoms Scale (PANSS), the Global Assessment of 
      Functioning (GAF), the Hamilton Depression Rating Scale (HDRS21) and the Young 
      Mania Rating Scale (YMRS). A statistically significant increase in the plasma 
      levels of IGF-1 was found in the whole cohort of patients one month after FPE 
      compared to matched controls (219.84 ng/ml vs 164.15 ng/ml; p=0.014), as well as 
      in schizophrenia patients alone at that stage (237.60 ng/ml vs 171.60 ng/ml; 
      p=0.039). In turn, negative symptoms in both groups of patients were positively 
      correlated with IGF-1 levels both at FPE (beta=0.521; p<0.001) and after 1 year 
      (beta=0.659; p=0.001), being patients diagnosed with schizophrenia the main 
      contributors to this relationship. These results indicate that there is a 
      significant change in the plasma levels of IGF-1 at the initial stages of 
      schizophrenia but not in bipolar disorder, and suggest that IGF-1 could have role 
      in the pathophysiology of negative symptoms.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Palomino, Aitor
AU  - Palomino A
AD  - CIBERNED, Neuroscience Department and Achucarro Basque Center for Neuroscience, 
      University of the Basque Country, 48940, Vizcaya, Spain.
FAU - Gonzalez-Pinto, Ana
AU  - Gonzalez-Pinto A
FAU - Martinez-Cengotitabengoa, Monica
AU  - Martinez-Cengotitabengoa M
FAU - Ruiz de Azua, Sonia
AU  - Ruiz de Azua S
FAU - Alberich, Susana
AU  - Alberich S
FAU - Mosquera, Fernando
AU  - Mosquera F
FAU - Matute, Carlos
AU  - Matute C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130118
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Bipolar Disorder/*blood/*physiopathology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Male
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/*blood/*physiopathology
MH  - Statistics, Nonparametric
MH  - Young Adult
EDAT- 2013/01/23 06:00
MHDA- 2013/12/19 06:00
CRDT- 2013/01/23 06:00
PHST- 2012/10/01 00:00 [received]
PHST- 2012/12/10 00:00 [revised]
PHST- 2013/01/11 00:00 [accepted]
PHST- 2013/01/23 06:00 [entrez]
PHST- 2013/01/23 06:00 [pubmed]
PHST- 2013/12/19 06:00 [medline]
AID - S0278-5846(13)00010-9 [pii]
AID - 10.1016/j.pnpbp.2013.01.008 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jul 1;44:29-33. doi: 
      10.1016/j.pnpbp.2013.01.008. Epub 2013 Jan 18.