PMID- 23337714
OWN - NLM
STAT- MEDLINE
DCOM- 20130729
LR  - 20130205
IS  - 1473-558X (Electronic)
IS  - 0959-4965 (Linking)
VI  - 24
IP  - 4
DP  - 2013 Mar 6
TI  - Contribution of brain-derived neurotrophic factor to mechanical hyperalgesia 
      induced by ventral root transection in rats.
PG  - 167-70
LID - 10.1097/WNR.0b013e32835d4b97 [doi]
AB  - It is generally believed that the development of neuropathic pain primarily 
      results from injuries to sensory afferent fibers. Recent studies found that 
      injuries to the motor efferent fibers (e.g. ventral root transection) also 
      contribute to the development of neuropathic pain. Furthermore, an increase in 
      brain-derived neurotrophic factor (BDNF) synthesis has been found in the ventral 
      root transection model, suggesting a possible role of BDNF in this model. To 
      determine the role of BDNF, we observed the effects of intrathecal antibody 
      against BDNF treatment on ventral root transection-induced mechanical 
      hyperalgesia. Paw withdrawal thresholds to mechanical stimuli were measured 
      before and after surgery. The results showed that ventral root transection in 
      rats produced a significant, lasting decrease of mechanical withdrawal 
      thresholds, presenting the development of mechanical hyperalgesia. Intrathecal 
      antibody against BDNF treatment markedly inhibited ventral root 
      transection-induced mechanical hyperalgesia in a dose-related manner. The 
      findings suggest that BDNF-mediated signaling pathway within spinal cord may be 
      involved in the development of neuropathic pain involving injuries to motor 
      efferent fibers.
FAU - Chen, Hui-Sheng
AU  - Chen HS
AD  - Departments of Neurology, General Hospital of Shenyang Military Area Command, 
      Shen Yang, PR China. chszh@yahoo.com.cn
FAU - Zhou, Zhong-He
AU  - Zhou ZH
FAU - Li, Man
AU  - Li M
FAU - Wang, Jian-Xiu
AU  - Wang JX
FAU - Liu, Bao-Jun
AU  - Liu BJ
FAU - Lu, Yao
AU  - Lu Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Axotomy
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Disease Models, Animal
MH  - Hyperalgesia/*metabolism
MH  - Male
MH  - Neuralgia/*metabolism
MH  - Neurons, Efferent/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Signal Transduction/physiology
MH  - Spinal Nerve Roots/injuries/*metabolism
EDAT- 2013/01/23 06:00
MHDA- 2013/07/31 06:00
CRDT- 2013/01/23 06:00
PHST- 2013/01/23 06:00 [entrez]
PHST- 2013/01/23 06:00 [pubmed]
PHST- 2013/07/31 06:00 [medline]
AID - 10.1097/WNR.0b013e32835d4b97 [doi]
PST - ppublish
SO  - Neuroreport. 2013 Mar 6;24(4):167-70. doi: 10.1097/WNR.0b013e32835d4b97.