PMID- 23338778
OWN - NLM
STAT- MEDLINE
DCOM- 20130903
LR  - 20211021
IS  - 1860-1499 (Electronic)
IS  - 1860-1499 (Linking)
VI  - 46
IP  - 1
DP  - 2013 Mar
TI  - Chromophobe renal cell carcinoma, oncocytic variant: a proposal of a new variant 
      giving a critical diagnostic pitfall in diagnosing renal oncocytic tumors.
PG  - 49-55
LID - 10.1007/s00795-012-0007-7 [doi]
AB  - In chromophobe renal cell carcinoma (RCC), two forms of typical and eosinophilic 
      variants have been reported to date. We have previously reported a new variant of 
      chromophobe RCC, namely an oncocytic variant. However, little is known on the 
      histological features of this variant. In this article, we report such five 
      cases. Macroscopically, the tumor was well demarcated, but unencapsulated. The 
      cut surface of the tumor showed brown in color, but neither hemorrhage nor 
      necrosis was seen. Microscopically, the tumor consisted of predominant tubular 
      configuration with or without various proportion of solid-sheet pattern. In one 
      tumor, tumor cells microscopically invaded branches of renal vein. In addition, 
      the constituting cells were characterized by the oncocytic cytoplasm, trivial to 
      minimal variation in tumor size, indistinct to slightly distinct cell border, 
      centrally located round nuclei and the absence of perinuclear halo. These 
      characteristics entirely resembled renal oncocytoma. However, neoplastic cells 
      immunohistochemically showed the diffuse and strong labeling for cytokeratin 7 
      and mitochondrial antigen in all cases. In addition, in fluorescence in situ 
      hybridization (FISH) study the loss of more than four chromosomes among 
      chromosomes 7, 10, 13, 17 and 21 was confirmed in all tumors and the diagnosis of 
      chromophobe RCC was rendered. In conclusion, we propose a new variant, namely an 
      oncocytic variant, of chromophobe RCC morphologically resembling renal oncocytoma 
      and biologically showing characteristics of chromophobe RCC, and this recognition 
      is practically crucial in the differential diagnosis from renal oncocytoma.
FAU - Kuroda, Naoto
AU  - Kuroda N
AD  - Department of Diagnostic Pathology, Kochi Red Cross Hospital, Shin-honmachi 
      2-13-51, Kochi, Japan. kurochankochi@yahoo.co.jp
FAU - Tanaka, Azusa
AU  - Tanaka A
FAU - Yamaguchi, Tadanori
AU  - Yamaguchi T
FAU - Kasahara, Kotaro
AU  - Kasahara K
FAU - Naruse, Keishi
AU  - Naruse K
FAU - Yamada, Yosuke
AU  - Yamada Y
FAU - Hatanaka, Kanako
AU  - Hatanaka K
FAU - Shinohara, Nobuo
AU  - Shinohara N
FAU - Nagashima, Yoji
AU  - Nagashima Y
FAU - Mikami, Shuji
AU  - Mikami S
FAU - Oya, Mototsugu
AU  - Oya M
FAU - Hamashima, Takeru
AU  - Hamashima T
FAU - Michal, Michal
AU  - Michal M
FAU - Hes, Ondrej
AU  - Hes O
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130122
PL  - Japan
TA  - Med Mol Morphol
JT  - Medical molecular morphology
JID - 101239023
RN  - 0 (Autoantigens)
RN  - 0 (Keratin-7)
RN  - 0 (mitochondrial antigen 36 kDa)
RN  - Oncocytoma, renal
SB  - IM
MH  - Adenoma, Oxyphilic/*diagnosis/pathology
MH  - Aged
MH  - Aged, 80 and over
MH  - Autoantigens
MH  - Carcinoma, Renal Cell/*classification/*diagnosis/*pathology
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Keratin-7
MH  - Kidney Neoplasms/*diagnosis/pathology
MH  - Male
EDAT- 2013/01/23 06:00
MHDA- 2013/09/04 06:00
CRDT- 2013/01/23 06:00
PHST- 2012/05/09 00:00 [received]
PHST- 2012/07/02 00:00 [accepted]
PHST- 2013/01/23 06:00 [entrez]
PHST- 2013/01/23 06:00 [pubmed]
PHST- 2013/09/04 06:00 [medline]
AID - 10.1007/s00795-012-0007-7 [doi]
PST - ppublish
SO  - Med Mol Morphol. 2013 Mar;46(1):49-55. doi: 10.1007/s00795-012-0007-7. Epub 2013 
      Jan 22.