PMID- 23339049
OWN - NLM
STAT- MEDLINE
DCOM- 20130805
LR  - 20220408
IS  - 1872-8081 (Electronic)
IS  - 0951-6433 (Linking)
VI  - 39
IP  - 1
DP  - 2013 Jan-Feb
TI  - Curcumin and obesity.
PG  - 78-87
LID - 10.1002/biof.1074 [doi]
AB  - Turmeric has been long recognized for its anti-inflammatory and health-promoting 
      properties. Curcumin is one of the principal anti-inflammatory and healthful 
      components of turmeric comprising 2-8% of most turmeric preparations. 
      Experimental evidence supports the activity of curcumin in promoting weight loss 
      and reducing the incidence of obesity-related diseases. With the discovery that 
      obesity is characterized by chronic low-grade metabolic inflammation, 
      phytochemicals like curcumin which have anti-inflammatory activity are being 
      intensely investigated. Recent scientific research reveals that curcumin directly 
      interacts with white adipose tissue to suppress chronic inflammation. In adipose 
      tissue, curcumin inhibits macrophage infiltration and nuclear factor kappaB (NF-kappaB) 
      activation induced by inflammatory agents. Curcumin reduces the expression of the 
      potent proinflammatory adipokines tumor necrosis factor-alpha (TNFalpha), monocyte 
      chemoattractant protein-1 (MCP-1), and plasminogen activator inhibitor type-1 
      (PAI-1), and it induces the expression of adiponectin, the principal 
      anti-inflammatory agent secreted by adipocytes. Curcumin also has effects to 
      inhibit adipocyte differentiation and to promote antioxidant activities. Through 
      these diverse mechanisms curcumin reduces obesity and curtails the adverse health 
      effects of obesity.
CI  - Copyright (c) 2013 International Union of Biochemistry and Molecular Biology, Inc.
FAU - Bradford, Peter G
AU  - Bradford PG
AD  - Department of Pharmacology and Toxicology, School of Medicine and Biomedical 
      Sciences, State University of New York at Buffalo, Buffalo, NY 14214-3000, USA. 
      pgb@buffalo.edu
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130122
PL  - Netherlands
TA  - Biofactors
JT  - BioFactors (Oxford, England)
JID - 8807441
RN  - 0 (Adipokines)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Anti-Obesity Agents)
RN  - 0 (Inflammation Mediators)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Adipocytes/drug effects/physiology
MH  - Adipokines/metabolism
MH  - Adipose Tissue, White/drug effects/metabolism/pathology
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
MH  - Anti-Obesity Agents/*pharmacology
MH  - Cell Differentiation/drug effects
MH  - Curcumin/*pharmacology
MH  - Epigenesis, Genetic/drug effects
MH  - Humans
MH  - Inflammation Mediators/metabolism
MH  - Obesity/*drug therapy/metabolism/pathology
MH  - Signal Transduction/drug effects
EDAT- 2013/01/23 06:00
MHDA- 2013/08/06 06:00
CRDT- 2013/01/23 06:00
PHST- 2012/08/15 00:00 [received]
PHST- 2012/10/18 00:00 [accepted]
PHST- 2013/01/23 06:00 [entrez]
PHST- 2013/01/23 06:00 [pubmed]
PHST- 2013/08/06 06:00 [medline]
AID - 10.1002/biof.1074 [doi]
PST - ppublish
SO  - Biofactors. 2013 Jan-Feb;39(1):78-87. doi: 10.1002/biof.1074. Epub 2013 Jan 22.