PMID- 2333972
OWN - NLM
STAT- MEDLINE
DCOM- 19900605
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 258
IP  - 4 Pt 1
DP  - 1990 Apr
TI  - Effect of neurotensin on regional cerebral glucose utilization in cold 
      water-restrained rats.
PG  - G591-5
AB  - Neurotensin (NT), given intracerebroventricularly (icv), attenuates cold water 
      restraint (CWR)-induced gastric mucosal injury; however, it is not clear which 
      brain nuclear group or groups are involved. These studies tested the hypothesis 
      that neuronal function, as measured by regional cerebral metabolic rate for 
      glucose (rCMRGlc), is altered by icv NT with or without CWR. CWR resulted in a 
      reduced global glucose utilization of 72 and 65% in control and NT-treated rats, 
      respectively. NT, given icv, protected against ulcer formation induced by CWR. In 
      those rats given NT icv, rCMRGlc was elevated significantly in amygdala, nucleus 
      accumbens, substantia nigra, tuberculum olfactrium, hypothalamus, and cerebellum 
      compared with CWR rats without NT pretreatment. This rCMRGlc increase was 
      observed in both unstressed and stressed rats given NT icv in the nucleus 
      accumbens and amygdala. These observations suggest that the nucleus accumbens and 
      amygdala, both components of the mesolimbic dopamine system, are involved in the 
      central action of NT on the gastric mucosa.
FAU - Xing, L P
AU  - Xing LP
AD  - Department of Surgery, Milton S. Hershey Medical Center, Pennsylvania State 
      University, Hershey 17033.
FAU - King, J C
AU  - King JC
FAU - Bryan, R M
AU  - Bryan RM
FAU - Kauffman, G L Jr
AU  - Kauffman GL Jr
LA  - eng
GR  - R01-DK-38198/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Blood Glucose)
RN  - 39379-15-2 (Neurotensin)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Body Temperature
MH  - Brain/drug effects/*metabolism
MH  - Cold Temperature
MH  - Glucose/*metabolism
MH  - Male
MH  - Neurotensin/*pharmacology
MH  - Organ Specificity
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reference Values
MH  - Restraint, Physical
MH  - Stress, Physiological/*metabolism
EDAT- 1990/04/11 19:15
MHDA- 1990/04/11 19:16
CRDT- 1990/04/11 19:15
PHST- 1990/04/11 19:15 [pubmed]
PHST- 1990/04/11 19:16 [medline]
PHST- 1990/04/11 19:15 [entrez]
AID - 10.1152/ajpgi.1990.258.4.G591 [doi]
PST - ppublish
SO  - Am J Physiol. 1990 Apr;258(4 Pt 1):G591-5. doi: 10.1152/ajpgi.1990.258.4.G591.