PMID- 23340884
OWN - NLM
STAT- MEDLINE
DCOM- 20140203
LR  - 20220321
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Print)
IS  - 0149-5992 (Linking)
VI  - 36
IP  - 7
DP  - 2013 Jul
TI  - Identification of minimal clinically important difference scores of the PedsQL in 
      children, adolescents, and young adults with type 1 and type 2 diabetes.
PG  - 1891-7
LID - 10.2337/dc12-1708 [doi]
AB  - OBJECTIVE: To establish minimal clinically important difference (MCID) scores 
      representing the smallest detectable change in quality of life (QOL), using the 
      Pediatric Quality of Life Inventory (PedsQL) Generic Core and Diabetes Module 
      among youth with diabetes and their parents, and to identify demographic and 
      clinical correlates of QOL change over 1 year. RESEARCH DESIGN AND METHODS: 
      Participants in the SEARCH for Diabetes in Youth Study aged >5 years and parents 
      of youth aged <18 years completed PedsQL surveys at their initial and 12-month 
      study visits. MCIDs for each PedsQL module were calculated using one standard 
      error of measurement. Demographic and clinical characteristics associated with 
      QOL change were identified through multiple linear and logistic regression 
      analyses. RESULTS: The sample comprised 5,004 youth (mean age, 12.5 +/- 4.7 years; 
      mean diabetes duration, 3.4 +/- 3.7 years). Of 100 possible points, PedsQL total 
      score MCIDs for youth with type 1 and type 2 diabetes, respectively, were Generic 
      Core, 4.88, 6.27 (parent) and 4.72, 5.41 (youth); Diabetes Module, 4.54, 6.06 
      (parent) and 5.27, 5.96 (youth). Among 1,402 youth with a follow-up visit, lower 
      baseline QOL, male sex, private insurance, having type 1 diabetes, longer 
      diabetes duration, and better glycemic control predicted improvements in youth- 
      and parent-reported PedsQL total scores over 1 year. Clinically meaningful (>/=1 
      MCID) improvements in total score for at least one PedsQL module were predicted 
      by private insurance, lower BMI, and lower A1C at baseline. CONCLUSIONS: These 
      diabetes-specific reference points to interpret clinically meaningful change in 
      PedsQL scores can be used in clinical care and research for youth with type 1 and 
      type 2 diabetes.
FAU - Hilliard, Marisa E
AU  - Hilliard ME
AD  - Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, 
      Maryland, USA.
FAU - Lawrence, Jean M
AU  - Lawrence JM
FAU - Modi, Avani C
AU  - Modi AC
FAU - Anderson, Andrea
AU  - Anderson A
FAU - Crume, Tessa
AU  - Crume T
FAU - Dolan, Lawrence M
AU  - Dolan LM
FAU - Merchant, Anwar T
AU  - Merchant AT
FAU - Yi-Frazier, Joyce P
AU  - Yi-Frazier JP
FAU - Hood, Korey K
AU  - Hood KK
CN  - SEARCH for Diabetes in Youth Study Group
LA  - eng
GR  - U01 DP000247/DP/NCCDPHP CDC HHS/United States
GR  - U18 DP002710/DP/NCCDPHP CDC HHS/United States
GR  - U48/CCU419249/PHS HHS/United States
GR  - M01 RR000069/RR/NCRR NIH HHS/United States
GR  - 200-2010-35171/PHS HHS/United States
GR  - U18 DP002714/DP/NCCDPHP CDC HHS/United States
GR  - U58CCU919256/PHS HHS/United States
GR  - U48/CCU519239/PHS HHS/United States
GR  - UL1 RR029882/RR/NCRR NIH HHS/United States
GR  - P30 DK-57516/DK/NIDDK NIH HHS/United States
GR  - U01 DP000250/DP/NCCDPHP CDC HHS/United States
GR  - HIR 10-001/HX/HSRD VA/United States
GR  - U01 DP-000245/DP/NCCDPHP CDC HHS/United States
GR  - P30 DK057516/DK/NIDDK NIH HHS/United States
GR  - 1UL1 RR-026314-01/RR/NCRR NIH HHS/United States
GR  - M01 RR-00037/RR/NCRR NIH HHS/United States
GR  - U48/CCU819241-3/PHS HHS/United States
GR  - U01 DP000245/DP/NCCDPHP CDC HHS/United States
GR  - DP-05-069/DP/NCCDPHP CDC HHS/United States
GR  - UL1 RR-029882/RR/NCRR NIH HHS/United States
GR  - U18 DP-002708-01/DP/NCCDPHP CDC HHS/United States
GR  - U01 DP-000247/DP/NCCDPHP CDC HHS/United States
GR  - U18 DP-000247-06A1/DP/NCCDPHP CDC HHS/United States
GR  - U01 DP-000250/DP/NCCDPHP CDC HHS/United States
GR  - U01 DP-000244/DP/NCCDPHP CDC HHS/United States
GR  - U01 DP000248/DP/NCCDPHP CDC HHS/United States
GR  - U48/CCU919219/PHS HHS/United States
GR  - M01 RR000037/RR/NCRR NIH HHS/United States
GR  - U01 DP-000254/DP/NCCDPHP CDC HHS/United States
GR  - U01 DP000244/DP/NCCDPHP CDC HHS/United States
GR  - DP-10-001/DP/NCCDPHP CDC HHS/United States
GR  - U18 DP-002714/DP/NCCDPHP CDC HHS/United States
GR  - U18 DP-002710-01/DP/NCCDPHP CDC HHS/United States
GR  - CC999999/Intramural CDC HHS/United States
GR  - U01 DP-000248/DP/NCCDPHP CDC HHS/United States
GR  - U58/CCU019235-4/PHS HHS/United States
GR  - U18 DP002709/DP/NCCDPHP CDC HHS/United States
GR  - U01 DP-000246/DP/NCCDPHP CDC HHS/United States
GR  - K23 DK089017/DK/NIDDK NIH HHS/United States
GR  - U18 DP-002709/DP/NCCDPHP CDC HHS/United States
GR  - M01 RR-00069/RR/NCRR NIH HHS/United States
GR  - U01 DP000246/DP/NCCDPHP CDC HHS/United States
GR  - U01 DP000254/DP/NCCDPHP CDC HHS/United States
GR  - UL1 RR026314/RR/NCRR NIH HHS/United States
GR  - U18 DP002708/DP/NCCDPHP CDC HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20130122
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 1/*pathology
MH  - Diabetes Mellitus, Type 2/*pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Regression Analysis
MH  - Young Adult
PMC - PMC3687260
FIR - Lawrence, Jean M
IR  - Lawrence JM
FIR - Reynolds, Kristi
IR  - Reynolds K
FIR - Hsu, Jin-Wen
IR  - Hsu JW
FIR - Black, Mary Helen
IR  - Black MH
FIR - Holmquist, Kim
IR  - Holmquist K
FIR - Takhar, Harpreet S
IR  - Takhar HS
FIR - Kershnar, Ann K
IR  - Kershnar AK
FIR - Pettitt, David J
IR  - Pettitt DJ
FIR - Dabelea, Dana
IR  - Dabelea D
FIR - Hamman, Richard F
IR  - Hamman RF
FIR - Testaverde, Lisa
IR  - Testaverde L
FIR - Klingensmith, Georgeanna J
IR  - Klingensmith GJ
FIR - Rewers, Marian J
IR  - Rewers MJ
FIR - Maahs, David
IR  - Maahs D
FIR - Wadwa, Paul
IR  - Wadwa P
FIR - Daniels, Stephen
IR  - Daniels S
FIR - Nadeau, Kristen
IR  - Nadeau K
FIR - Bloch, Clifford A
IR  - Bloch CA
FIR - Sorrelman, Carmelita
IR  - Sorrelman C
FIR - Beartrack, Alfreda
IR  - Beartrack A
FIR - Rodriguez, Beatriz L
IR  - Rodriguez BL
FIR - Fujimoto, Wilfred
IR  - Fujimoto W
FIR - Curb, J David
IR  - Curb JD
FIR - Kennedy, Fiona
IR  - Kennedy F
FIR - Uramoto, Greg
IR  - Uramoto G
FIR - Waxman, Sorrell
IR  - Waxman S
FIR - Chung, Richard
IR  - Chung R
FIR - Waitzfelder, Beth
IR  - Waitzfelder B
FIR - Hillier, Teresa
IR  - Hillier T
FIR - Dolan, Lawrence M
IR  - Dolan LM
FIR - Seid, Michael
IR  - Seid M
FIR - Urbina, Elaine
IR  - Urbina E
FIR - Standiford, Debra A
IR  - Standiford DA
FIR - Mayer-Davis, Elizabeth J
IR  - Mayer-Davis EJ
FIR - Thomas, Joan
IR  - Thomas J
FIR - Merchant, Anwar
IR  - Merchant A
FIR - Liese, Angela D
IR  - Liese AD
FIR - Moran, Robert R
IR  - Moran RR
FIR - Gaillard-McBride, Gladys
IR  - Gaillard-McBride G
FIR - Lawler, Deborah
IR  - Lawler D
FIR - Jackson, Malaka
IR  - Jackson M
FIR - Bowlby, Deborah
IR  - Bowlby D
FIR - Amrhein, James
IR  - Amrhein J
FIR - Clark, Pam
IR  - Clark P
FIR - Parker, Mark
IR  - Parker M
FIR - Pihoker, Catherine
IR  - Pihoker C
FIR - Afkarian, Maryam
IR  - Afkarian M
FIR - Badaru, Angela
IR  - Badaru A
FIR - Gilliam, Lisa
IR  - Gilliam L
FIR - Hirsch, Irl
IR  - Hirsch I
FIR - Liu, Lenna L
IR  - Liu LL
FIR - Neff, John
IR  - Neff J
FIR - Yi-Frazier, Joyce
IR  - Yi-Frazier J
FIR - Loots, Beth
IR  - Loots B
FIR - O'Connor, Rebecca
IR  - O'Connor R
FIR - Kearns, Sue
IR  - Kearns S
FIR - Klingsheim, Mary
IR  - Klingsheim M
FIR - Buscaino, Emil
IR  - Buscaino E
FIR - Cochrane, Katherine
IR  - Cochrane K
FIR - Martinez, Onel
IR  - Martinez O
FIR - Semana, Sharla
IR  - Semana S
FIR - Greenbaum, Carla
IR  - Greenbaum C
FIR - Imperatore, Giuseppina
IR  - Imperatore G
FIR - Williams, Desmond E
IR  - Williams DE
FIR - Kahn, Henry S
IR  - Kahn HS
FIR - Moore, Bernice
IR  - Moore B
FIR - Edward, Gregg W
IR  - Edward GW
FIR - Saydah, Sharon H
IR  - Saydah SH
FIR - Linder, Barbara
IR  - Linder B
FIR - Marcovina, Santica M
IR  - Marcovina SM
FIR - Gaur, Vinod P
IR  - Gaur VP
FIR - Harting, Jessica
IR  - Harting J
FIR - Bell, Ronny
IR  - Bell R
FIR - D'Agostino, Ralph Jr
IR  - D'Agostino R Jr
FIR - Beech, Bettina
IR  - Beech B
FIR - Case, Douglas
IR  - Case D
FIR - Divers, Jasmin
IR  - Divers J
FIR - Morgan, Timothy
IR  - Morgan T
FIR - Naughton, Michelle
IR  - Naughton M
FIR - Henkin, Leora
IR  - Henkin L
FIR - Moxley, Susan
IR  - Moxley S
FIR - Hargis, Gena
IR  - Hargis G
FIR - Kronner, Donna
IR  - Kronner D
FIR - Goldstein, Maureen T
IR  - Goldstein MT
FIR - Anderson, Andrea
IR  - Anderson A
FIR - Andrews, Jeanette
IR  - Andrews J
FIR - Lauer, Abigail
IR  - Lauer A
FIR - Talton, Jennifer
IR  - Talton J
EDAT- 2013/01/24 06:00
MHDA- 2014/02/04 06:00
PMCR- 2014/07/01
CRDT- 2013/01/24 06:00
PHST- 2013/01/24 06:00 [entrez]
PHST- 2013/01/24 06:00 [pubmed]
PHST- 2014/02/04 06:00 [medline]
PHST- 2014/07/01 00:00 [pmc-release]
AID - dc12-1708 [pii]
AID - 1708 [pii]
AID - 10.2337/dc12-1708 [doi]
PST - ppublish
SO  - Diabetes Care. 2013 Jul;36(7):1891-7. doi: 10.2337/dc12-1708. Epub 2013 Jan 22.