PMID- 23341348
OWN - NLM
STAT- MEDLINE
DCOM- 20130711
LR  - 20211021
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 133
IP  - 2
DP  - 2013 Jul 15
TI  - Insulin-like growth factor pathway genes and blood concentrations, dietary 
      protein and risk of prostate cancer in the NCI Breast and Prostate Cancer Cohort 
      Consortium (BPC3).
PG  - 495-504
LID - 10.1002/ijc.28042 [doi]
AB  - It has been hypothesized that a high intake of dairy protein may increase 
      prostate cancer risk by increasing the production of insulin-like growth factor 1 
      (IGF-1). Several single nucleotide polymorphisms (SNPs) have been weakly 
      associated with circulating concentrations of IGF-1 and IGF binding protein 3 
      (IGFBP-3), but none of these SNPs was associated with risk of prostate cancer. We 
      examined whether an association between 16 SNPs associated with circulating IGF-1 
      or IGFBP-3 concentrations and prostate cancer exists within subgroups defined by 
      dietary protein intake in 5,253 cases and 4,963 controls of European ancestry 
      within the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). The BPC3 
      includes nested case-control studies within large North-American and European 
      cohorts. Per-allele odds ratios for prostate cancer for the SNPs were compared 
      across tertiles of protein intake, which was expressed as the percentage of 
      energy derived from total, animal, dairy or plant protein sources, using 
      conditional logistic regression models. Total, animal, dairy and plant protein 
      intakes were significantly positively associated with blood IGF-1 (p < 0.01), but 
      not with IGFBP-3 concentrations (p > 0.10) or with risk of prostate cancer 
      (p > 0.20). After adjusting for multiple testing, the SNP-prostate cancer 
      associations did not differ by intakes of protein, although two interactions by 
      intake of plant protein were of marginal statistical significance [SSTR5 
      (somatostatin receptor 5)-rs197056 (uncorrected p for interaction, 0.001); 
      SSTR5-rs197057 (uncorrected p for interaction, 0.002)]. We found no strong 
      evidence that the associations between 16 IGF pathway SNPs and prostate cancer 
      differed by intakes of dietary protein.
CI  - Copyright (c) 2013 UICC.
FAU - Tsilidis, Konstantinos K
AU  - Tsilidis KK
AD  - Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of 
      Oxford, Oxford, United Kingdom. kostas.tsilidis@ceu.ox.ac.uk
FAU - Travis, Ruth C
AU  - Travis RC
FAU - Appleby, Paul N
AU  - Appleby PN
FAU - Allen, Naomi E
AU  - Allen NE
FAU - Lindstrom, Sara
AU  - Lindstrom S
FAU - Albanes, Demetrius
AU  - Albanes D
FAU - Ziegler, Regina G
AU  - Ziegler RG
FAU - McCullough, Marjorie L
AU  - McCullough ML
FAU - Siddiq, Afshan
AU  - Siddiq A
FAU - Barricarte, Aurelio
AU  - Barricarte A
FAU - Berndt, Sonja I
AU  - Berndt SI
FAU - Bueno-de-Mesquita, H Bas
AU  - Bueno-de-Mesquita HB
FAU - Chanock, Stephen J
AU  - Chanock SJ
FAU - Crawford, E David
AU  - Crawford ED
FAU - Diver, W Ryan
AU  - Diver WR
FAU - Gapstur, Susan M
AU  - Gapstur SM
FAU - Giovannucci, Edward
AU  - Giovannucci E
FAU - Gu, Fangyi
AU  - Gu F
FAU - Haiman, Christopher A
AU  - Haiman CA
FAU - Hayes, Richard B
AU  - Hayes RB
FAU - Hunter, David J
AU  - Hunter DJ
FAU - Johansson, Mattias
AU  - Johansson M
FAU - Kaaks, Rudolf
AU  - Kaaks R
FAU - Kolonel, Laurence N
AU  - Kolonel LN
FAU - Kraft, Peter
AU  - Kraft P
FAU - Le Marchand, Loic
AU  - Le Marchand L
FAU - Overvad, Kim
AU  - Overvad K
FAU - Polidoro, Silvia
AU  - Polidoro S
FAU - Riboli, Elio
AU  - Riboli E
FAU - Schumacher, Fredrick R
AU  - Schumacher FR
FAU - Stevens, Victoria L
AU  - Stevens VL
FAU - Trichopoulos, Dimitrios
AU  - Trichopoulos D
FAU - Virtamo, Jarmo
AU  - Virtamo J
FAU - Willett, Walter C
AU  - Willett WC
FAU - Key, Timothy J
AU  - Key TJ
LA  - eng
GR  - U01-CA98233-07/CA/NCI NIH HHS/United States
GR  - U01-CA98710-06/CA/NCI NIH HHS/United States
GR  - U01-CA98216-06/CA/NCI NIH HHS/United States
GR  - U01 CA098216/CA/NCI NIH HHS/United States
GR  - U01 CA098233/CA/NCI NIH HHS/United States
GR  - U01 CA098758/CA/NCI NIH HHS/United States
GR  - U01-CA98758-07/CA/NCI NIH HHS/United States
GR  - P30 CA071789/CA/NCI NIH HHS/United States
GR  - U01 CA098710/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130215
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Aged
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Diet
MH  - Genotype
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/blood/*genetics
MH  - Insulin-Like Growth Factor I/*genetics/metabolism
MH  - Male
MH  - Middle Aged
MH  - Models, Biological
MH  - Odds Ratio
MH  - Polymorphism, Single Nucleotide
MH  - Prostatic Neoplasms/blood/*genetics
MH  - Regression Analysis
MH  - Risk Factors
PMC - PMC3656134
MID - NIHMS444257
EDAT- 2013/01/24 06:00
MHDA- 2013/07/13 06:00
PMCR- 2014/07/15
CRDT- 2013/01/24 06:00
PHST- 2012/10/05 00:00 [received]
PHST- 2012/12/17 00:00 [accepted]
PHST- 2013/01/24 06:00 [entrez]
PHST- 2013/01/24 06:00 [pubmed]
PHST- 2013/07/13 06:00 [medline]
PHST- 2014/07/15 00:00 [pmc-release]
AID - 10.1002/ijc.28042 [doi]
PST - ppublish
SO  - Int J Cancer. 2013 Jul 15;133(2):495-504. doi: 10.1002/ijc.28042. Epub 2013 Feb 
      15.