PMID- 23343330
OWN - NLM
STAT- MEDLINE
DCOM- 20141010
LR  - 20220316
IS  - 1751-7893 (Electronic)
IS  - 1751-7885 (Linking)
VI  - 8
IP  - 1
DP  - 2014 Feb
TI  - Clinical outcomes of long-acting risperidone in recent versus long-term diagnosed 
      Belgian schizophrenic patients: results from electronic Schizophrenia Treatment 
      Adherence Registry (e-STAR) and Trial for the Initiation and Maintenance Of 
      REmission in Schizophrenia with risperidone (TIMORES).
PG  - 39-49
LID - 10.1111/eip.12017 [doi]
AB  - AIM: Potential differences in psychiatric clinical outcomes and hospitalization 
      rates before and after the initiation of long-acting risperidone among recently 
      and long-term diagnosed schizophrenia patients were studied. METHODS: Data from 
      two observational studies (Trial for the Initiation and Maintenance Of REmission 
      in Schizophrenia with risperidone (TIMORES) and electronic Schizophrenia 
      Treatment Adherence Registry (e-STAR)) were categorized by the recency of their 
      diagnose and compared in several post hoc analyses. Clinical Global Impression of 
      illness Severity (CGI-S) and Global Assessment of Functioning (GAF) scores, as 
      well as symptoms of clinical deterioration (including hospitalization data) at 
      baseline, 12-month (for TIMORES and e-STAR) and 24-month (for e-STAR) follow-up 
      were analysed. Other outcome measures included discontinuation rate, employment 
      status and remission attainment. RESULTS: Statistically significantly differences 
      between recent and long-term diagnosed schizophrenic patients at 12- and 24-month 
      follow-up were found for CGI-S (between P < 0.01 and P </= 0.001) and GAF 
      (P < 0.05) scores. Other differences between both schizophrenic patient groups 
      were found for measures of clinical deterioration, employment status and full 
      symptomatic remission rates at 1 year. Although no consistent difference was 
      found between recent and long-term patient groups for hospitalization parameters, 
      the difference in length of full hospitalization days was statistically 
      significantly different (P < 0.01) between e-STAR 'Early' and 'Late' patient 
      groups at both 12- and 24-month endpoints: the mean change from baseline was 
      significantly greater for e-STAR 'Early' at 12 months, but greater for e-STAR 
      'Late' at 24 months. CONCLUSIONS: The findings of the post hoc analyses support 
      the significance of pharmacological interventions, such as long-acting 
      risperidone, in addressing discontinuity issues, especially in recently diagnosed 
      patients.
CI  - (c) 2013 Wiley Publishing Asia Pty Ltd.
FAU - Dubois, Vincent
AU  - Dubois V
AD  - Service de Psychiatrie Adulte, Cliniques Universitaires St Luc, Bruxelles, 
      Belgium.
FAU - Peuskens, Joseph
AU  - Peuskens J
FAU - Geerts, Paul
AU  - Geerts P
FAU - Detraux, Johan
AU  - Detraux J
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20130124
PL  - Australia
TA  - Early Interv Psychiatry
JT  - Early intervention in psychiatry
JID - 101320027
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Delayed-Action Preparations)
RN  - L6UH7ZF8HC (Risperidone)
SB  - IM
MH  - Adult
MH  - Antipsychotic Agents/*therapeutic use
MH  - Belgium
MH  - Delayed-Action Preparations/therapeutic use
MH  - Early Medical Intervention
MH  - Employment
MH  - Female
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - *Registries
MH  - Remission Induction
MH  - Risperidone/administration & dosage/*therapeutic use
MH  - Schizophrenia/diagnosis/*drug therapy
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - clinical outcome
OT  - first-episode psychosis
OT  - hospitalization
OT  - long-acting risperidone
EDAT- 2013/01/25 06:00
MHDA- 2014/10/11 06:00
CRDT- 2013/01/25 06:00
PHST- 2012/04/06 00:00 [received]
PHST- 2012/09/16 00:00 [accepted]
PHST- 2013/01/25 06:00 [entrez]
PHST- 2013/01/25 06:00 [pubmed]
PHST- 2014/10/11 06:00 [medline]
AID - 10.1111/eip.12017 [doi]
PST - ppublish
SO  - Early Interv Psychiatry. 2014 Feb;8(1):39-49. doi: 10.1111/eip.12017. Epub 2013 
      Jan 24.