PMID- 23346966
OWN - NLM
STAT- MEDLINE
DCOM- 20150420
LR  - 20211021
IS  - 1369-1600 (Electronic)
IS  - 1355-6215 (Print)
IS  - 1355-6215 (Linking)
VI  - 19
IP  - 4
DP  - 2014 Jul
TI  - Opioid system in the medial prefrontal cortex mediates binge-like eating.
PG  - 652-62
LID - 10.1111/adb.12033 [doi]
AB  - Binge eating disorder is an addiction-like disorder characterized by excessive 
      food consumption within discrete periods of time. This study was aimed at 
      understanding the role of the opioid system within the medial prefrontal cortex 
      (mPFC) in the consummatory and motivational aspects of binge-like eating. For 
      this purpose, we trained male rats to obtain either a sugary, highly palatable 
      diet (Palatable rats) or a chow diet (Chow rats) for 1 hour/day. We then 
      evaluated the effects of the opioid receptor antagonist, naltrexone, given either 
      systemically or site-specifically into the nucleus accumbens (NAcc) or the mPFC 
      on a fixed ratio 1 (FR1) and a progressive ratio schedule of reinforcement for 
      food. Finally, we assessed the expression of the genes proopiomelanocortin 
      (POMC), pro-dynorphin (PDyn) and pro-enkephalin (PEnk), coding for the opioids 
      peptides in the NAcc and the mPFC in both groups. Palatable rats rapidly 
      escalated their intake by four times. Naltrexone, when administered systemically 
      and into the NAcc, reduced FR1 responding for food and motivation to eat under a 
      progressive ratio in both Chow and Palatable rats; conversely, when administered 
      into the mPFC, the effects were highly selective for binge eating rats. 
      Furthermore, we found a twofold increase in POMC and a  approximately 50% reduction in PDyn 
      gene expression in the mPFC of Palatable rats, when compared to control rats; 
      however, no changes were observed in the NAcc. Our data suggest that 
      neuroadaptations of the opioid system in the mPFC occur following intermittent 
      access to highly palatable food, which may be responsible for the development of 
      binge-like eating.
CI  - (c) 2013 The Authors, Addiction Biology (c) 2013 Society for the Study of Addiction.
FAU - Blasio, Angelo
AU  - Blasio A
AD  - Laboratory of Addictive Disorders, Departments of Pharmacology and Psychiatry, 
      Boston University School of Medicine, Boston, MA, USA.
FAU - Steardo, Luca
AU  - Steardo L
FAU - Sabino, Valentina
AU  - Sabino V
FAU - Cottone, Pietro
AU  - Cottone P
LA  - eng
GR  - R01 DA030425/DA/NIDA NIH HHS/United States
GR  - K99 AA016731/AA/NIAAA NIH HHS/United States
GR  - AA016731/AA/NIAAA NIH HHS/United States
GR  - R01 MH091945/MH/NIMH NIH HHS/United States
GR  - R00 AA016731/AA/NIAAA NIH HHS/United States
GR  - DA030425/DA/NIDA NIH HHS/United States
GR  - MH091945/MH/NIMH NIH HHS/United States
GR  - MH093650A1/MH/NIMH NIH HHS/United States
GR  - K99 DA023680/DA/NIDA NIH HHS/United States
GR  - R01 MH093650/MH/NIMH NIH HHS/United States
GR  - DA023680/DA/NIDA NIH HHS/United States
GR  - R00 DA023680/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20130124
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
RN  - 0 (Narcotic Antagonists)
RN  - 0 (Opioid Peptides)
RN  - 5S6W795CQM (Naltrexone)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Binge-Eating Disorder/*prevention & control
MH  - Conditioning, Operant
MH  - Disease Models, Animal
MH  - Feeding Behavior/*drug effects
MH  - Male
MH  - Motivation/drug effects
MH  - Naltrexone/*pharmacology
MH  - Narcotic Antagonists/pharmacology
MH  - Opioid Peptides/*physiology
MH  - Prefrontal Cortex/*drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Reinforcement, Psychology
PMC - PMC3664255
MID - NIHMS431519
OTO - NOTNLM
OT  - Addiction
OT  - binge eating disorder
OT  - nucleus accumbens
OT  - opioid
OT  - palatability
OT  - prefrontal cortex
EDAT- 2013/01/26 06:00
MHDA- 2015/04/22 06:00
PMCR- 2015/07/01
CRDT- 2013/01/26 06:00
PHST- 2013/01/26 06:00 [entrez]
PHST- 2013/01/26 06:00 [pubmed]
PHST- 2015/04/22 06:00 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - 10.1111/adb.12033 [doi]
PST - ppublish
SO  - Addict Biol. 2014 Jul;19(4):652-62. doi: 10.1111/adb.12033. Epub 2013 Jan 24.