PMID- 23347665
OWN - NLM
STAT- MEDLINE
DCOM- 20130426
LR  - 20221207
IS  - 1755-3768 (Electronic)
IS  - 1755-375X (Linking)
VI  - 91
IP  - 1
DP  - 2013 Feb
TI  - Multicenter Spanish study of spectral-domain optical coherence tomography in 
      normal children.
PG  - e56-63
LID - 10.1111/j.1755-3768.2012.02562.x [doi]
AB  - PURPOSE: To compile a multicenter normative database of retinal nerve fibre layer 
      (RNFL) and macular thicknesses and macular volume values in healthy Caucasian 
      children 4-17 years using spectral-domain optical coherence tomography (SD-OCT). 
      To analyse variations in the OCT measurements as a function of age, sex, 
      refraction, and axial length (AL). METHODS: An observational, multicenter and 
      cross-sectional study among 301 healthy Caucasian children recruited at three 
      Spanish centres was performed. To compile the database, each child underwent a 
      dilated eye examination and a cycloplegic refraction, five AL measurements (IOL 
      Master; Carl Zeiss Meditec, Dublin, CA, USA), five OCT scans with Cirrus OCT: 
      three peripapillary RNFL scans (Optic Disc Cube 200X200 protocol) and two macular 
      scans (Macular Cube 512X128 protocol). One eye of each subject was selected 
      randomly for analysis. RESULTS: Two hundred eighty-three children (117 boys, 
      41.34%; 166 girls, 58.66%) were included in this study. The mean age of the 
      children was 9.58 +/- 3.12 years (range, 4-17). The mean SE was +0.63 +/- 1.65 D; 
      (range, -4.88 to +5.25). The mean AL was 22.94 +/- 1.10 mm (range, 20.10-26.27). 
      The mean global RNFL thickness was 97.40 +/- 9.0 mum (range, 77-121.7 mum). 
      Multivariate analysis showed a positive correlation between the RNFL and 
      spherical equivalent (SE) (p = 0.014). The mean central macular thickness was 
      253.85 +/- 19.76 mum, the average thickness 283.62 +/- 14.08 mum, and the mean macular 
      volume 10.22 +/- 0.49 mum(3) . Multivariate analysis showed a positive correlation 
      between central macular thickness and age (p < 0.001). Boys had a significantly 
      thicker central macula than girls (p < 0.001). CONCLUSIONS: Normative paediatric 
      SD-OCT data might facilitate use of SD-OCT for assessing childhood ophthalmic 
      diseases. This study provides a multicenter paediatric normative database of 
      SD-OCT peripapillary RNFL and macular data.
CI  - (c) 2013 The Authors. Acta Ophthalmologica (c) 2013 Acta Ophthalmologica Scandinavica 
      Foundation.
FAU - Barrio-Barrio, Jesus
AU  - Barrio-Barrio J
AD  - Department of Ophthalmology, Clinica Universidad de Navarra, University of 
      Navarra, Pamplona, Spain. jbarrio@unav.es
FAU - Noval, Susana
AU  - Noval S
FAU - Galdos, Marta
AU  - Galdos M
FAU - Ruiz-Canela, Miguel
AU  - Ruiz-Canela M
FAU - Bonet, Elvira
AU  - Bonet E
FAU - Capote, Maria
AU  - Capote M
FAU - Lopez, Maialen
AU  - Lopez M
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - England
TA  - Acta Ophthalmol
JT  - Acta ophthalmologica
JID - 101468102
SB  - IM
MH  - Adolescent
MH  - Age Distribution
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Macula Lutea/*anatomy & histology
MH  - Male
MH  - *Nerve Fibers
MH  - Reference Values
MH  - Retinal Ganglion Cells/*cytology
MH  - Sex Distribution
MH  - Spain
MH  - *Tomography, Optical Coherence
MH  - White People
EDAT- 2013/01/26 06:00
MHDA- 2013/04/27 06:00
CRDT- 2013/01/26 06:00
PHST- 2013/01/26 06:00 [entrez]
PHST- 2013/01/26 06:00 [pubmed]
PHST- 2013/04/27 06:00 [medline]
AID - 10.1111/j.1755-3768.2012.02562.x [doi]
PST - ppublish
SO  - Acta Ophthalmol. 2013 Feb;91(1):e56-63. doi: 10.1111/j.1755-3768.2012.02562.x.