PMID- 23348639
OWN - NLM
STAT- MEDLINE
DCOM- 20140106
LR  - 20220317
IS  - 1809-4546 (Electronic)
IS  - 0100-6991 (Linking)
VI  - 39
IP  - 6
DP  - 2012 Dec
TI  - Ingestion of glutamine and maltodextrin two hours preoperatively improves insulin 
      sensitivity after surgery: a randomized, double blind, controlled trial.
PG  - 449-55
LID - S0100-69912012000600002 [pii]
AB  - OBJECTIVE: To investigate whether the abbreviation of preoperative fasting with a 
      drink containing glutamine and dextrinomaltose improves organic response to 
      surgical trauma. METHODS: Thirty-six female patients adult (18-62 years) 
      candidates for elective laparoscopic cholecystectomy were randomly divided into 
      three groups: conventional fasting (fasting group), and two groups receiving two 
      different diets, eight hours (400ml) and two hours before induction of anesthesia 
      (200ml): carbohydrate (CHO) group (12.5% dextrinomaltose) and the glutamine (GLN) 
      group (12.5% dextrinomaltose and 40 and 10g of glutamine, respectively). Blood 
      samples were collected pre and postoperatively. RESULTS: Twenty-eight patients 
      completed the study. No pulmonary complication occurred. Gastric residual volume 
      was similar between groups (p = 0.95). Postoperatively, all patients from the 
      fasting group had abnormal glucose (> 110mg/dl), this abnormality being of 50% 
      when compared to the CHO group (p = 0.14), and of 22.2% when compared to the GLN 
      group (p = 0.01). All patients who had the fasting period shortened (CHO + GLN) 
      had normal postoperative insulin, contrasting with 66.7% in the fasted group (p = 
      0.02). The abnormal sensitivity to insulin postoperatively rose from 32.1% to 
      46.4% of cases (p = 0.24), and it occurred in only 11.1% of patients in GLN group 
      when compared to 55.5% in the fasting group (p = 0.02). CONCLUSION: the 
      abbreviation of preoperative fasting for two hours with dextrinomaltose and 
      glutamine improves insulin sensitivity in patients undergoing elective 
      laparoscopic cholecystectomy.
FAU - Dock-Nascimento, Diana Borges
AU  - Dock-Nascimento DB
AD  - School of Nutrition, Federal University of Mato Grosso, Cuiaba, Mato Grosso - MT, 
      Brazil. dianadock@hotmail.com
FAU - Aguilar-Nascimento, Jose Eduardo de
AU  - Aguilar-Nascimento JE
FAU - Linetzky Waitzberg, Dan
AU  - Linetzky Waitzberg D
LA  - eng
LA  - por
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Brazil
TA  - Rev Col Bras Cir
JT  - Revista do Colegio Brasileiro de Cirurgioes
JID - 7809515
RN  - 0 (Polysaccharides)
RN  - 0RH81L854J (Glutamine)
RN  - 7CVR7L4A2D (maltodextrin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Double-Blind Method
MH  - Female
MH  - Glutamine/*therapeutic use
MH  - Humans
MH  - *Insulin Resistance
MH  - Middle Aged
MH  - Polysaccharides/*therapeutic use
MH  - *Preoperative Care
MH  - Prospective Studies
MH  - Time Factors
MH  - Young Adult
EDAT- 2013/01/26 06:00
MHDA- 2014/01/07 06:00
CRDT- 2013/01/26 06:00
PHST- 2012/05/15 00:00 [received]
PHST- 2012/07/18 00:00 [accepted]
PHST- 2013/01/26 06:00 [entrez]
PHST- 2013/01/26 06:00 [pubmed]
PHST- 2014/01/07 06:00 [medline]
AID - S0100-69912012000600002 [pii]
AID - 10.1590/s0100-69912012000600002 [doi]
PST - ppublish
SO  - Rev Col Bras Cir. 2012 Dec;39(6):449-55. doi: 10.1590/s0100-69912012000600002.