PMID- 23348864
OWN - NLM
STAT- MEDLINE
DCOM- 20140129
LR  - 20130626
IS  - 1539-2864 (Electronic)
IS  - 0275-004X (Linking)
VI  - 33
IP  - 7
DP  - 2013 Jul-Aug
TI  - Spectral-domain optical coherence tomography of early onset large colloid drusen.
PG  - 1346-50
LID - 10.1097/IAE.0b013e318283127d [doi]
AB  - PURPOSE: Large colloid drusen (LCD) are a subgroup of early onset drusen recently 
      reported. The aim of this study was to describe morphologic features in patients 
      affected with LCD using high-resolution spectral-domain optical coherence 
      tomography (SD-OCT). METHODS: A complete ophthalmologic examination including 
      SD-OCT was performed in 22 eyes of 11 consecutive patients. RESULTS: Mean age was 
      35 years old at diagnosis, and mean visual acuity was 20/25. In all eyes, SD-OCT 
      showed multiple dome-shaped retinal pigment epithelium detachments corresponding 
      to the drusen. Mean height of drusen was 199 mum (range, 108-316 mum) and mean 
      width was 419 mum (range, 190-681 mum). Indocyanine green angiography 
      hypofluorescent LCD were larger and more reflective on SD-OCT than indocyanine 
      green angiography hyperfluorescent LCD. All drusen appeared convex with medium 
      and homogeneous internal reflectivity. Retina overlying LCD appeared wavy and 
      overall thinned. Prominent diffuse hyperreflective haze in the Henle fiber layer 
      over drusen was noted in 73% of the eyes. No geographic atrophy or choroidal 
      neovascularization was observed. CONCLUSION: The peculiar SD-OCT features 
      reported in the current series give insight on the ultrastructure of LCD. Further 
      studies with follow-up evaluation and possibly histologic evaluation are needed 
      to clarify the clinical significance of LCD.
FAU - Guigui, Benjamin
AU  - Guigui B
AD  - Creteil University Eye Clinic, Faculte de Medecine Henri Mondor, 40 avenue de 
      Verdun, Creteil, France.
FAU - Querques, Giuseppe
AU  - Querques G
FAU - Leveziel, Nicolas
AU  - Leveziel N
FAU - Bouakkaz, Hassiba
AU  - Bouakkaz H
FAU - Massamba, Nathalie
AU  - Massamba N
FAU - Coscas, Gabriel
AU  - Coscas G
FAU - Souied, Eric H
AU  - Souied EH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Retina
JT  - Retina (Philadelphia, Pa.)
JID - 8309919
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Female
MH  - Fluorescein Angiography
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multimodal Imaging
MH  - Retinal Drusen/*pathology
MH  - Tomography, Optical Coherence/*methods
EDAT- 2013/01/26 06:00
MHDA- 2014/01/30 06:00
CRDT- 2013/01/26 06:00
PHST- 2013/01/26 06:00 [entrez]
PHST- 2013/01/26 06:00 [pubmed]
PHST- 2014/01/30 06:00 [medline]
AID - 10.1097/IAE.0b013e318283127d [doi]
PST - ppublish
SO  - Retina. 2013 Jul-Aug;33(7):1346-50. doi: 10.1097/IAE.0b013e318283127d.