PMID- 23349048
OWN - NLM
STAT- MEDLINE
DCOM- 20131119
LR  - 20211021
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Print)
IS  - 0887-8013 (Linking)
VI  - 27
IP  - 2
DP  - 2013 Mar
TI  - The role of serum VCAM-1 and TNF-alpha as predictors of mortality and morbidity in 
      patients with chronic heart failure.
PG  - 105-12
LID - 10.1002/jcla.21570 [doi]
AB  - BACKGROUND: To assess the prognostic significance of four inflammatory markers 
      (TNF-alpha, high sensitive C-reactive protein (hs-CRP), intercellular cell adhesion 
      molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1)) in chronic heart 
      failure (CHF) patients with respect to individual outcomes, especially disease 
      exacerbation and mortality. METHODS: Plasma adhesion molecules, ICAM-1, and 
      VCAM-1, together with TNF-alpha and hs-CRP were determined in 120 CHF patients and 69 
      healthy controls. Endothelial function was also estimated by flow-mediated 
      brachial artery dilatation. RESULTS: Increased levels of all investigated 
      inflammatory markers were found in CHF patients compared to controls, with the 
      rise more pronounced in New York Heart association (NYHA) functional IV class. 
      Significant correlations were obtained for VCAM-1 and brain natriuretic peptide 
      (r = 0.191; P = 0.038), as well as, ICAM-1 and endothelium-dependent 
      vasodilatation (r = -0.235; P = 0.01). Kaplan-Meier analysis showed disease 
      exacerbation in patients with TNF-alpha levels >2.78 pg/ml significantly shorter 
      compared to those with TNF-alpha levels <2.78 pg/ml (log-rank test = 8.270; P = 
      0.004), while similar association was observed for patients with hs-CRP levels 
      >4.76 mg/l (log-rank test = 5.052; P = 0.025) and VCAM-1 levels >1200 ng/l 
      (log-rank test = 5.45; P = 0.020) with respect to mortality. Cox regression 
      analysis demonstrated only VCAM-1 (HR = 4.7; 95% confidence interval (CI): 
      1.1-18.7; P = 0.030) as independent death predictor, while TNF-alpha was associated 
      with disease exacerbation (HR = 8.2; 95%CI: 1.1-23.0; P = 0.045). CONCLUSIONS: 
      VCAM-1 appears to be useful in risk stratification of CHF patients and in 
      screening, to identify subjects at risk for heart failure related events.
CI  - (c) 2013 Wiley Periodicals, Inc.
FAU - Savic-Radojevic, Ana
AU  - Savic-Radojevic A
AD  - Institute of Medical and Clinical Biochemistry, Faculty of Medicine, University 
      of Belgrade, Serbia.
FAU - Radovanovic, Slavica
AU  - Radovanovic S
FAU - Pekmezovic, Tatjana
AU  - Pekmezovic T
FAU - Pljesa-Ercegovac, Marija
AU  - Pljesa-Ercegovac M
FAU - Simic, Dragan
AU  - Simic D
FAU - Djukic, Tatjana
AU  - Djukic T
FAU - Matic, Marija
AU  - Matic M
FAU - Simic, Tatjana
AU  - Simic T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130124
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
RN  - 0 (Biomarkers)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Analysis of Variance
MH  - Biomarkers/blood
MH  - C-Reactive Protein/metabolism
MH  - Chronic Disease
MH  - Female
MH  - Heart Failure/*blood
MH  - Humans
MH  - Inflammation/blood
MH  - Intercellular Adhesion Molecule-1/blood
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Morbidity
MH  - Tumor Necrosis Factor-alpha/*blood
MH  - Vascular Cell Adhesion Molecule-1/*blood
PMC - PMC6807553
EDAT- 2013/01/26 06:00
MHDA- 2013/11/20 06:00
PMCR- 2013/01/24
CRDT- 2013/01/26 06:00
PHST- 2012/07/20 00:00 [received]
PHST- 2012/12/14 00:00 [accepted]
PHST- 2013/01/26 06:00 [entrez]
PHST- 2013/01/26 06:00 [pubmed]
PHST- 2013/11/20 06:00 [medline]
PHST- 2013/01/24 00:00 [pmc-release]
AID - JCLA21570 [pii]
AID - 10.1002/jcla.21570 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2013 Mar;27(2):105-12. doi: 10.1002/jcla.21570. Epub 2013 Jan 
      24.