PMID- 23349224
OWN - NLM
STAT- MEDLINE
DCOM- 20141216
LR  - 20171116
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Linking)
VI  - 24
IP  - 6
DP  - 2014 Jun
TI  - NMDA and AMPA/kainate glutamatergic receptors in the prelimbic medial prefrontal 
      cortex modulate the elaborated defensive behavior and innate fear-induced 
      antinociception elicited by GABAA receptor blockade in the medial hypothalamus.
PG  - 1518-28
LID - 10.1093/cercor/bht001 [doi]
AB  - The aim of the present study was to investigate the involvement of 
      N-methyl-d-aspartate (NMDA) and amino-3-hydroxy-5-methyl-isoxazole-4-proprionate 
      (AMPA)/kainate receptors of the prelimbic (PL) division of the medial prefrontal 
      cortex (MPFC) on the panic attack-like reactions evoked by gamma-aminobutyric acid-A 
      receptor blockade in the medial hypothalamus (MH). Rats were pretreated with NaCl 
      0.9%, LY235959 (NMDA receptor antagonist), and NBQX (AMPA/kainate receptor 
      antagonist) in the PL at 3 different concentrations. Ten minutes later, the MH 
      was treated with bicuculline, and the defensive responses were recorded for 10 
      min. The antagonism of NMDA receptors in the PL decreased the frequency and 
      duration of all defensive behaviors evoked by the stimulation of the MH and 
      reduced the innate fear-induced antinociception. However, the pretreatment of the 
      PL cortex with NBQX was able to decrease only part of defensive responses and 
      innate fear-induced antinociception. The present findings suggest that the 
      NMDA-glutamatergic system of the PL is critically involved in panic-like 
      responses and innate fear-induced antinociception and those AMPA/kainate 
      receptors are also recruited during the elaboration of fear-induced 
      antinociception and in panic attack-related response. The activation of the 
      glutamatergic neurotransmission of PL division of the MPFC during the elaboration 
      of oriented behavioral reactions elicited by the chemical stimulation of the MH 
      recruits mainly NMDA receptors in comparison with AMPA/kainate receptors.
FAU - de Freitas, Renato Leonardo
AU  - de Freitas RL
AD  - Departamento de Farmacologia, Laboratorio de Neuroanatomia & Neuropsicobiologia.
FAU - Salgado-Rohner, Carlos Jose
AU  - Salgado-Rohner CJ
FAU - Biagioni, Audrey Francisco
AU  - Biagioni AF
FAU - Medeiros, Priscila
AU  - Medeiros P
FAU - Hallak, Jaime Eduardo Cecilio
AU  - Hallak JE
FAU - Crippa, Jose Alexandre S
AU  - Crippa JA
FAU - Coimbra, Norberto Cysne
AU  - Coimbra NC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130124
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (GABA-A Receptor Antagonists)
RN  - 0 (Isoquinolines)
RN  - 0 (Quinoxalines)
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, GABA-A)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 118876-58-7 (2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline)
RN  - AR2BHC0C6P (LY 235959)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - Animals
MH  - Behavior, Animal/drug effects/*physiology
MH  - Bicuculline/pharmacology
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Fear/drug effects/*physiology
MH  - GABA-A Receptor Antagonists/pharmacology
MH  - Hypothalamus, Middle/drug effects/*physiology
MH  - Isoquinolines/pharmacology
MH  - Male
MH  - Nociceptive Pain/drug therapy/physiopathology
MH  - Pain Perception/drug effects/*physiology
MH  - Panic/drug effects/*physiology
MH  - Prefrontal Cortex/drug effects/*physiology
MH  - Quinoxalines/pharmacology
MH  - Rats, Wistar
MH  - Receptors, AMPA/antagonists & inhibitors/metabolism
MH  - Receptors, GABA-A/metabolism
MH  - Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors/metabolism
MH  - Synaptic Transmission/drug effects/physiology
OTO - NOTNLM
OT  - N-methyl-d-aspartate receptors
OT  - amino-3-hydroxy-5-methyl-isoxazole-4-proprionate/kainate receptors
OT  - dorsomedial hypothalamus
OT  - innate fear-induced antinociception
OT  - panic-like behavior, prelimbic medial prefrontal cortex
OT  - gamma-aminobutyric acid-A receptors
EDAT- 2013/01/26 06:00
MHDA- 2014/12/17 06:00
CRDT- 2013/01/26 06:00
PHST- 2013/01/26 06:00 [entrez]
PHST- 2013/01/26 06:00 [pubmed]
PHST- 2014/12/17 06:00 [medline]
AID - bht001 [pii]
AID - 10.1093/cercor/bht001 [doi]
PST - ppublish
SO  - Cereb Cortex. 2014 Jun;24(6):1518-28. doi: 10.1093/cercor/bht001. Epub 2013 Jan 
      24.