PMID- 23349383
OWN - NLM
STAT- MEDLINE
DCOM- 20131021
LR  - 20220419
IS  - 1469-0756 (Electronic)
IS  - 0032-5473 (Linking)
VI  - 89
IP  - 1051
DP  - 2013 May
TI  - Pulmonary-renal syndrome: a life threatening but treatable condition.
PG  - 274-83
LID - 10.1136/postgradmedj-2012-131416 [doi]
AB  - Pulmonary renal syndrome (PRS) describes the occurrence of renal failure in 
      association with respiratory failure, characterised by autoimmune-mediated 
      rapidly progressive glomerulonephritis (RPGN) and diffuse alveolar haemorrhage 
      (DAH), respectively. PRS is associated with significant morbidity and mortality, 
      and prompt diagnosis and treatment significantly improve outcomes. Prompt 
      diagnosis of PRS requires a high index of suspicion, as clinical features are 
      non-specific, and immunological testing aids the diagnosis in many cases. The 
      diagnostic evaluation of DAH and RPGN is outlined in the context of the important 
      differential diagnoses. The commonest causes of PRS include antineutrophil 
      cytoplasm antibody (ANCA)-associated vasculitis and antiglomerular basement 
      membrane disease. As such, more emphasis has been placed on these two conditions 
      in addition to an overview of the less common causes of PRS. We provide a 
      practical review of the diagnostic evaluation, current treatment strategies and 
      clinical outcomes of PRS for renal, respiratory and general physicians.
FAU - West, Stephen C
AU  - West SC
AD  - Renal Section, Department of Medicine, Hammersmith Hospital, 5th Floor 
      Commonwealth Building, Ducane Road, London W12 0NN, UK.
FAU - Arulkumaran, Nishkantha
AU  - Arulkumaran N
FAU - Ind, Philip W
AU  - Ind PW
FAU - Pusey, Charles D
AU  - Pusey CD
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130124
PL  - England
TA  - Postgrad Med J
JT  - Postgraduate medical journal
JID - 0234135
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - Rapidly progressive glomerulonephritis with pulmonary hemorrhage
SB  - IM
MH  - Anti-Glomerular Basement Membrane Disease/complications/*diagnosis/drug therapy
MH  - Antibodies, Antineutrophil Cytoplasmic/immunology
MH  - Diagnosis, Differential
MH  - Glomerulonephritis/*diagnosis/*drug therapy
MH  - Hemorrhage/*diagnosis/*drug therapy
MH  - Humans
MH  - Lung Diseases/*diagnosis/*drug therapy
MH  - Renal Insufficiency
MH  - Respiratory Insufficiency/complications/drug therapy
MH  - Treatment Outcome
MH  - Vasculitis/complications/*diagnosis/drug therapy
EDAT- 2013/01/26 06:00
MHDA- 2013/10/22 06:00
CRDT- 2013/01/26 06:00
PHST- 2013/01/26 06:00 [entrez]
PHST- 2013/01/26 06:00 [pubmed]
PHST- 2013/10/22 06:00 [medline]
AID - postgradmedj-2012-131416 [pii]
AID - 10.1136/postgradmedj-2012-131416 [doi]
PST - ppublish
SO  - Postgrad Med J. 2013 May;89(1051):274-83. doi: 10.1136/postgradmedj-2012-131416. 
      Epub 2013 Jan 24.