PMID- 23349740
OWN - NLM
STAT- MEDLINE
DCOM- 20130709
LR  - 20220316
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 8
IP  - 1
DP  - 2013
TI  - Telomerase reverse transcriptase synergizes with calorie restriction to increase 
      health span and extend mouse longevity.
PG  - e53760
LID - 10.1371/journal.pone.0053760 [doi]
LID - e53760
AB  - Caloric restriction (CR), a reduction of food intake while avoiding malnutrition, 
      can delay the onset of cancer and age-related diseases in several species, 
      including mice. In addition, depending of the genetic background, CR can also 
      increase or decrease mouse longevity. This has highlighted the importance of 
      identifying the molecular pathways that interplay with CR in modulating 
      longevity. Significant lifespan extension in mice has been recently achieved 
      through over-expression of the catalytic subunit of mouse telomerase (mTERT) in a 
      cancer protective background. Given the CR cancer-protective effects in rodents, 
      we set to address here whether CR impacts on telomere length and synergizes with 
      mTERT to extend mouse longevity. CR significantly decreased tumor incidence in 
      TERT transgenic (TgTERT) mice and extended their lifespan compared to wild-type 
      (WT) controls under the same diet, indicating a synergy between TgTERT and CR in 
      increasing mouse longevity. In addition, longitudinal telomere length 
      measurements in peripheral blood leukocytes from individual mice showed that CR 
      resulted in maintenance and/or elongation telomeres in a percentage of WT mice, a 
      situation that mimics telomere dynamics in TgTERT cohorts. These results 
      demonstrate that CR attenuates telomere erosion associated to aging and that 
      synergizes with TERT over-expression in increasing "health span" and extending 
      mouse longevity.
FAU - Vera, Elsa
AU  - Vera E
AD  - Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National 
      Cancer Research Centre, Melchor Fernandez Almagro 3, Madrid, Spain.
FAU - Bernardes de Jesus, Bruno
AU  - Bernardes de Jesus B
FAU - Foronda, Miguel
AU  - Foronda M
FAU - Flores, Juana M
AU  - Flores JM
FAU - Blasco, Maria A
AU  - Blasco MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130122
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Biomarkers)
RN  - EC 2.7.7.49 (Telomerase)
SB  - IM
MH  - Aging/genetics/physiology
MH  - Animals
MH  - Biomarkers/metabolism
MH  - Body Weight/genetics/physiology
MH  - *Caloric Restriction
MH  - Chromosome Aberrations
MH  - *Health
MH  - Humans
MH  - Longevity/genetics/*physiology
MH  - Longitudinal Studies
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Telomerase/genetics/*metabolism
MH  - Telomere/genetics
MH  - Telomere Shortening/genetics/physiology
PMC - PMC3551964
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2013/01/26 06:00
MHDA- 2013/07/10 06:00
PMCR- 2013/01/22
CRDT- 2013/01/26 06:00
PHST- 2012/09/28 00:00 [received]
PHST- 2012/12/04 00:00 [accepted]
PHST- 2013/01/26 06:00 [entrez]
PHST- 2013/01/26 06:00 [pubmed]
PHST- 2013/07/10 06:00 [medline]
PHST- 2013/01/22 00:00 [pmc-release]
AID - PONE-D-12-29821 [pii]
AID - 10.1371/journal.pone.0053760 [doi]
PST - ppublish
SO  - PLoS One. 2013;8(1):e53760. doi: 10.1371/journal.pone.0053760. Epub 2013 Jan 22.