PMID- 23351237
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130319
LR  - 20240322
IS  - 1560-8115 (Print)
IS  - 2008-2231 (Electronic)
IS  - 1560-8115 (Linking)
VI  - 20
IP  - 1
DP  - 2012 Dec 23
TI  - Role of testosterone in memory impairment of Alzheimer disease induced by 
      Streptozotocin in male rats.
PG  - 98
LID - 10.1186/2008-2231-20-98 [doi]
AB  - BACKGROUND AND PURPOSE OF THE STUDY: Recent studies demonstrate that androgens, 
      beyond regulating sexual behavior, exert several neuroprotective functions in the 
      brain. The present study was designed to explore effect of testosterone in memory 
      impairment induced by intra- cerebroventricular (icv) injection of streptozotocin 
      (STZ) as a model of sporadic AD. METHODS: Study was carried out on male Wistar 
      rats. Animals were randomly divided into 11 equal groups. Experimental model of 
      AD was induced by bilateral icv injection of STZ at the dose of 750 mug/Rat/10 mul 
      ACSF at days 1 and 3. STZ-induced memory impairment was assessed two weeks after 
      the last dose of STZ by using a passive avoidance task (1 mA). The interval 
      between the placement of animals in the illuminated chamber and the entry into 
      the dark chamber was measured as a step-through latency (STL). Castration was 
      performed by surgical removing of testis and behavioral study of memory 
      impairment was done after 4 weeks. RESULTS: Results of this study showed that icv 
      injection of STZ could induce marked (p < 0.05) memory impairment at the dose of 
      750 mug/Rat/dissolve10 mul CSF/bilateral/days 1 and 3. Therefore, we used this dose 
      of STZ for induction of experimental model of AD. Memory was worsened in 
      castrated rats (P < 0.05) when compared with normal and sham-operated animals. 
      Testosterone replacement therapy (1 mg/kg, sc, for 6 days) in 4 week castrated 
      rats restored memory up to the level of control groups. Testosterone had not any 
      significant effect on memory impairments of non-castrated rats. MAJOR CONCLUSION: 
      According to the obtained results it can be concluded that testosterone improves 
      cognitive and memory impairment of AD. We suggest that testosterone replacement 
      therapy may have beneficial effect in ameliorating memory impairments of senile 
      patients suffering from AD. Further clinical studies should be carried out to 
      prove possible useful effect of testosterone as an adjuvant therapy in AD.
FAU - Seyedreza, Pourrabi
AU  - Seyedreza P
AD  - Department of pharmacology and toxicology, Tabriz University of Medical Sciences, 
      Tabriz, 51664, Iran. nayebia@tbzmed.ac.ir.
FAU - Alireza, Mohajjel Nayebi
AU  - Alireza MN
FAU - Seyedebrahim, Hossini
AU  - Seyedebrahim H
LA  - eng
PT  - Journal Article
DEP - 20121223
PL  - Switzerland
TA  - Daru
JT  - Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
JID - 101125969
PMC - PMC3598779
EDAT- 2013/01/29 06:00
MHDA- 2013/01/29 06:01
PMCR- 2012/12/23
CRDT- 2013/01/29 06:00
PHST- 2012/09/24 00:00 [received]
PHST- 2012/12/11 00:00 [accepted]
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/01/29 06:01 [medline]
PHST- 2012/12/23 00:00 [pmc-release]
AID - 2008-2231-20-98 [pii]
AID - 10.1186/2008-2231-20-98 [doi]
PST - epublish
SO  - Daru. 2012 Dec 23;20(1):98. doi: 10.1186/2008-2231-20-98.