PMID- 23351271
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130328
LR  - 20220321
IS  - 1560-8115 (Print)
IS  - 2008-2231 (Electronic)
IS  - 1560-8115 (Linking)
VI  - 20
IP  - 1
DP  - 2012 Aug 28
TI  - Effect of vitamin D on insulin resistance and anthropometric parameters in Type 2 
      diabetes; a randomized double-blind clinical trial.
PG  - 10
LID - 10.1186/2008-2231-20-10 [doi]
AB  - BACKGROUND & THE PURPOSE OF THE STUDY: Prevalence of type 2 diabetes mellitus 
      (T2DM) is increasing worldwide. To reduce its risk and progression, preventive 
      strategies are needed. Vitamin supplementation such as vitamin D is one of the 
      strategies. This study was designed to investigate the effect of injection of 
      vitamin D on insulin resistance and anthropometric parameters in T2DM. METHODS: 
      This randomized double-blind clinical trial was conducted with 42 diabetic 
      patients in two groups; intervention group with single intramuscular injection of 
      300,000 International Unit (IU) of vitamin D3 and the placebo group. After 
      recording demographic and anthropometric factors (waist circumference, blood 
      pressure and body mass index), fasting blood samples was taken for measurement of 
      blood glucose, 25-hydroxyvitamin D3 (25-OHD3), insulin, glycosylated hemoglobin 
      A1c (HbA1c) and estimation of Homeostasis Model Assessment Index (HOMA) in two 
      times; before study and after three months. RESULTS: Two groups had similar 
      baseline characteristics (each group = 21 subjects). Three months after vitamin D 
      injection, HbA1c, anthropometric factors and HOMA index in intervention group 
      stayed constant, however, serum 25- OHD3 was significantly increased (p = 0.007). 
      CONCLUSION: The present data is not convincing and further studies with large 
      sample sizes are needed to show the definite effect of injection of vitamin D on 
      control of diabetes and its risk.
FAU - Heshmat, Ramin
AU  - Heshmat R
AD  - Endocrinology and Metabolism Research Center, Tehran University of Medical 
      Sciences, 5th floor, Dr, Shariati Hospital, North Kargar Ave, 14114 Tehran, Iran. 
      otabatabaeimla@yahoo.com
FAU - Tabatabaei-Malazy, Ozra
AU  - Tabatabaei-Malazy O
FAU - Abbaszadeh-Ahranjani, Shabnam
AU  - Abbaszadeh-Ahranjani S
FAU - Shahbazi, Samimeh
AU  - Shahbazi S
FAU - Khooshehchin, Ghazal
AU  - Khooshehchin G
FAU - Bandarian, Fathemeh
AU  - Bandarian F
FAU - Larijani, Bagher
AU  - Larijani B
LA  - eng
PT  - Journal Article
DEP - 20120828
PL  - Switzerland
TA  - Daru
JT  - Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
JID - 101125969
PMC - PMC3555787
EDAT- 2013/01/29 06:00
MHDA- 2013/01/29 06:01
PMCR- 2012/08/28
CRDT- 2013/01/29 06:00
PHST- 2012/07/06 00:00 [received]
PHST- 2012/07/10 00:00 [accepted]
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/01/29 06:01 [medline]
PHST- 2012/08/28 00:00 [pmc-release]
AID - 2008-2231-20-10 [pii]
AID - 10.1186/2008-2231-20-10 [doi]
PST - epublish
SO  - Daru. 2012 Aug 28;20(1):10. doi: 10.1186/2008-2231-20-10.