PMID- 23352235
OWN - NLM
STAT- MEDLINE
DCOM- 20130412
LR  - 20221109
IS  - 1097-4180 (Electronic)
IS  - 1074-7613 (Linking)
VI  - 38
IP  - 2
DP  - 2013 Feb 21
TI  - Human inflammatory dendritic cells induce Th17 cell differentiation.
PG  - 336-48
LID - S1074-7613(13)00010-1 [pii]
LID - 10.1016/j.immuni.2012.10.018 [doi]
AB  - Dendritic cells (DCs) are critical regulators of immune responses. Under 
      noninflammatory conditions, several human DC subsets have been identified. Little 
      is known, however, about the human DC compartment under inflammatory conditions. 
      Here, we characterize a DC population found in human inflammatory fluids that 
      displayed a phenotype distinct from macrophages from the same fluids and from 
      steady-state lymphoid organ and blood DCs. Transcriptome analysis showed that 
      they correspond to a distinct DC subset and share gene signatures with in vitro 
      monocyte-derived DCs. Moreover, human inflammatory DCs, but not inflammatory 
      macrophages, stimulated autologous memory CD4(+) T cells to produce 
      interleukin-17 and induce T helper 17 (Th17) cell differentiation from naive 
      CD4(+) T cells through the selective secretion of Th17 cell-polarizing cytokines. 
      We conclude that inflammatory DCs represent a distinct human DC subset and 
      propose that they are derived from monocytes and are involved in the induction 
      and maintenance of Th17 cell responses.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Segura, Elodie
AU  - Segura E
AD  - INSERM U932, 26 rue d'Ulm, 75005 Paris, France.
FAU - Touzot, Maxime
AU  - Touzot M
FAU - Bohineust, Armelle
AU  - Bohineust A
FAU - Cappuccio, Antonio
AU  - Cappuccio A
FAU - Chiocchia, Gilles
AU  - Chiocchia G
FAU - Hosmalin, Anne
AU  - Hosmalin A
FAU - Dalod, Marc
AU  - Dalod M
FAU - Soumelis, Vassili
AU  - Soumelis V
FAU - Amigorena, Sebastian
AU  - Amigorena S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130124
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (CD4 Antigens)
RN  - 0 (Interleukin-17)
SB  - IM
MH  - CD4 Antigens/genetics/immunology
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Dendritic Cells/immunology/*pathology
MH  - Humans
MH  - Immunologic Memory
MH  - Inflammation/genetics/immunology/*pathology
MH  - Interleukin-17/biosynthesis/*immunology
MH  - Lymphocyte Activation
MH  - Macrophages/immunology/*pathology
MH  - Monocytes/immunology/*pathology
MH  - Organ Specificity
MH  - Signal Transduction
MH  - Th1-Th2 Balance
MH  - Th17 Cells/immunology/*pathology
MH  - Transcriptome/immunology
EDAT- 2013/01/29 06:00
MHDA- 2013/04/13 06:00
CRDT- 2013/01/29 06:00
PHST- 2012/05/11 00:00 [received]
PHST- 2012/10/09 00:00 [accepted]
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/04/13 06:00 [medline]
AID - S1074-7613(13)00010-1 [pii]
AID - 10.1016/j.immuni.2012.10.018 [doi]
PST - ppublish
SO  - Immunity. 2013 Feb 21;38(2):336-48. doi: 10.1016/j.immuni.2012.10.018. Epub 2013 
      Jan 24.