PMID- 23352343
OWN - NLM
STAT- MEDLINE
DCOM- 20130604
LR  - 20220321
IS  - 1879-1891 (Electronic)
IS  - 0002-9394 (Linking)
VI  - 155
IP  - 5
DP  - 2013 May
TI  - Angiographic and optical coherence tomography characteristics of recent myopic 
      choroidal neovascularization.
PG  - 913-9
LID - S0002-9394(12)00832-X [pii]
LID - 10.1016/j.ajo.2012.11.021 [doi]
AB  - PURPOSE: To analyze the contribution of fluorescein angiography (FA) and 
      spectral-domain optical coherence tomography (SD OCT) to the diagnosis of recent 
      choroidal neovascularization (CNV) associated with high myopia. DESIGN: 
      Retrospective, observational case series. METHODS: Ninety eyes of 73 highly 
      myopic patients (refractive error >/=-6 diopters) with CNV in 1 or both eyes were 
      included. Epidemiologic features, refractive error, fundus examination, 
      fluorescein angiography, and SD OCT findings at onset of CNV were analyzed. 
      RESULTS: Mean age at onset of CNV was 54.4 +/- 14 years. CNV was bilateral in 17 of 
      73 cases. Mean refractive error was -13.9 +/- 5.2 diopters. Myopic CNV was 
      associated more frequently with patchy or geographic atrophy (P = .019). CNV was 
      associated with exudative features on fluorescein angiography in 82% of cases 
      (64/78), and on SD OCT in 48.6% of cases (36/74). There was no agreement about 
      signs of active CNV between these 2 imaging methods (kappa = 25.7 +/- 10%; P = .0044). 
      CNV area was significantly smaller in younger patients (<55 years) than in older 
      patients (0.57 mm(2) vs 1.21 mm(2), respectively; P = .023). CONCLUSIONS: 
      Exudative features of myopic CNV are more obvious on FA than on SD OCT, 
      suggesting that fluorescein angiography should be performed when new-onset myopic 
      CNV is suspected. Myopic CNV occurring in older patients (>/=55 years) is larger 
      than those seen in younger patients and resembles CNV associated with age-related 
      macular degeneration. This suggests an overlap between myopic CNV in older 
      patients and age-related macular degeneration.
CI  - Copyright (c) 2013 Elsevier Inc. All rights reserved.
FAU - Leveziel, Nicolas
AU  - Leveziel N
AD  - Faculte de Medecine Henri Mondor, Department of Ophthalmology, Assistance 
      Publique Hopitaux de Paris, Groupe Hospitalier Albert Chenevier-Henri Mondor, 
      Universite Paris Est Creteil, Creteil, France. nicolas.leveziel@chu-poitiers.fr
FAU - Caillaux, Violaine
AU  - Caillaux V
FAU - Bastuji-Garin, Sylvie
AU  - Bastuji-Garin S
FAU - Zmuda, Mathieu
AU  - Zmuda M
FAU - Souied, Eric H
AU  - Souied EH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20130123
PL  - United States
TA  - Am J Ophthalmol
JT  - American journal of ophthalmology
JID - 0370500
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Choroid/*pathology
MH  - Choroidal Neovascularization/complications/*diagnosis
MH  - Diagnosis, Differential
MH  - Female
MH  - Fluorescein Angiography/*methods
MH  - Fundus Oculi
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myopia/complications/*diagnosis
MH  - Ophthalmoscopy
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Tomography, Optical Coherence/*methods
MH  - Young Adult
EDAT- 2013/01/29 06:00
MHDA- 2013/06/05 06:00
CRDT- 2013/01/29 06:00
PHST- 2012/06/18 00:00 [received]
PHST- 2012/11/17 00:00 [revised]
PHST- 2012/11/26 00:00 [accepted]
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/06/05 06:00 [medline]
AID - S0002-9394(12)00832-X [pii]
AID - 10.1016/j.ajo.2012.11.021 [doi]
PST - ppublish
SO  - Am J Ophthalmol. 2013 May;155(5):913-9. doi: 10.1016/j.ajo.2012.11.021. Epub 2013 
      Jan 23.