PMID- 23352660
OWN - NLM
STAT- MEDLINE
DCOM- 20130709
LR  - 20130226
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 537
DP  - 2013 Mar 14
TI  - Voluntary resistance running induces increased hippocampal neurogenesis in rats 
      comparable to load-free running.
PG  - 6-10
LID - S0304-3940(13)00022-0 [pii]
LID - 10.1016/j.neulet.2013.01.005 [doi]
AB  - Recently, we reported that voluntary resistance wheel running with a resistance 
      of 30% of body weight (RWR), which produces shorter distances but higher work 
      levels, enhances spatial memory associated with hippocampal brain-derived 
      neurotrophic factor (BDNF) signaling compared to wheel running without a load 
      (WR) [17]. We thus hypothesized that RWR promotes adult hippocampal neurogenesis 
      (AHN) as a neuronal substrate underlying this memory improvement. Here we used 
      10-week-old male Wistar rats divided randomly into sedentary (Sed), WR, and RWR 
      groups. All rats were injected intraperitoneally with the thymidine analogue 
      5-Bromo-2'-deoxuridine (BrdU) for 3 consecutive days before wheel running. We 
      found that even when the average running distance decreased by about half, the 
      average work levels significantly increased in the RWR group, which caused 
      muscular adaptation (oxidative capacity) for fast-twitch plantaris muscle without 
      causing any negative stress effects. Additionally, immunohistochemistry revealed 
      that the total BrdU-positive cells and newborn mature cells (BrdU/NeuN 
      double-positive) in the dentate gyrus increased in both the WR and RWR groups. 
      These results provide new evidence that RWR has beneficial effects on AHN 
      comparable to WR, even with short running distances.
CI  - Copyright (c) 2013 Elsevier Ireland Ltd. All rights reserved.
FAU - Lee, Min Chul
AU  - Lee MC
AD  - Laboratory of Exercise Biochemistry and Neuroendocrinology, Faculty of Health and 
      Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8574, Japan.
FAU - Inoue, Koshiro
AU  - Inoue K
FAU - Okamoto, Masahiro
AU  - Okamoto M
FAU - Liu, Yu Fan
AU  - Liu YF
FAU - Matsui, Takashi
AU  - Matsui T
FAU - Yook, Jang Soo
AU  - Yook JS
FAU - Soya, Hideaki
AU  - Soya H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130122
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
SB  - IM
MH  - Animals
MH  - Hippocampus/*cytology
MH  - Male
MH  - Muscle, Skeletal/physiology
MH  - Neurogenesis
MH  - *Physical Conditioning, Animal
MH  - Rats
MH  - Rats, Wistar
MH  - Running
MH  - Weight-Bearing
EDAT- 2013/01/29 06:00
MHDA- 2013/07/10 06:00
CRDT- 2013/01/29 06:00
PHST- 2012/10/01 00:00 [received]
PHST- 2012/12/03 00:00 [revised]
PHST- 2013/01/02 00:00 [accepted]
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/07/10 06:00 [medline]
AID - S0304-3940(13)00022-0 [pii]
AID - 10.1016/j.neulet.2013.01.005 [doi]
PST - ppublish
SO  - Neurosci Lett. 2013 Mar 14;537:6-10. doi: 10.1016/j.neulet.2013.01.005. Epub 2013 
      Jan 22.