PMID- 2335368
OWN - NLM
STAT- MEDLINE
DCOM- 19900613
LR  - 20180215
IS  - 0001-5652 (Print)
IS  - 0001-5652 (Linking)
VI  - 40
IP  - 2
DP  - 1990
TI  - A genetic study of immunoglobulin E and atopic disease based on families 
      ascertained through asthmatic children.
PG  - 69-76
AB  - In order to investigate the modes of inheritance of serum immunoglobulin E (IgE) 
      levels and atopic disease, serum IgE levels and data on allergic disease were 
      obtained from 42 families ascertained through asthmatic children visiting an 
      allergy clinic. Although the mean IgE levels were elevated (mean 637 U/ml), the 
      prevalence of atopic disease in this population was surprisingly low. When the 
      data were analyzed using complex segregation analysis, no major locus could be 
      detected. Moreover, the polygenic heritability was unexpectedly small even though 
      the correlation between serum IgE levels and the liability to atopic disease was 
      around 0.4. Given this unusual set of findings, it is postulated that parasitic 
      infections in this population have (in accordance with well-established results 
      of parasitic disease) caused both elevated levels of serum IgE and a decreased 
      prevalence of allergic disease with the possible masking of the various genetic 
      components of serum IgE levels and atopic disease.
FAU - Parks, T
AU  - Parks T
AD  - Division of Biostatistics, Washington University School of Medicine, St. Louis, 
      Mo.
FAU - Felix, K
AU  - Felix K
FAU - Rice, T
AU  - Rice T
FAU - Subbarao, P V
AU  - Subbarao PV
FAU - Marimuthu, K M
AU  - Marimuthu KM
FAU - Rao, D C
AU  - Rao DC
LA  - eng
GR  - GM28719/GM/NIGMS NIH HHS/United States
GR  - HL33973/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Hum Hered
JT  - Human heredity
JID - 0200525
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Asthma/*genetics
MH  - Computer Simulation
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/*genetics
MH  - Immunoglobulin E/*genetics
MH  - India
MH  - Male
MH  - Models, Genetic
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
AID - 10.1159/000153908 [doi]
PST - ppublish
SO  - Hum Hered. 1990;40(2):69-76. doi: 10.1159/000153908.