PMID- 23354536
OWN - NLM
STAT- MEDLINE
DCOM- 20131028
LR  - 20211021
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 227
IP  - 2
DP  - 2013 May
TI  - Effects of repeated exposure to MDMA on 5HT1a autoreceptor function: behavioral 
      and neurochemical responses to 8-OHDPAT.
PG  - 355-61
LID - 10.1007/s00213-013-2980-5 [doi]
AB  - A consistent effect of repeated exposure to 3,4 methylenedioxymethamphetamine 
      (MDMA) is a decrease in the tissue levels of serotonin (5-HT). A variety of 
      behavioural and neurochemical tests were conducted to determine whether the 
      tissue deficits were accompanied by an increased sensitivity of the 5-HT1a 
      autoreceptor. Tests were conducted 2 weeks following MDMA exposure (four 
      injections of 10.0 mg/kg, IP, administered at 2-h intervals in a single day). The 
      response to the 5-HT1a agonist, 8-OHDPAT (0.003-0.5 mg/kg, SC), was assessed 
      using lower lip retraction (LLR), hypoactivity, and 5-hydroxytryptophan (5-HTP) 
      accumulation following decarboxylase inhibition. The 8-OHDPAT produced a 
      dose-dependent increase in LLR and hypoactivity, but these effects were 
      comparable for MDMA and saline pretreated groups. MDMA decreased tissue levels of 
      5-HT and the accumulation of 5-HTP, but these effects were not reflected in the 
      changes in autoreceptor sensitivity. The data suggest that the decrease in tissue 
      levels of 5-HT produced by MDMA is accompanied by a decrease in tryptophan 
      hydroxylase activity but cannot be explained by supersensitivity of the 5-HT1a 
      autoreceptor.
FAU - Schenk, Susan
AU  - Schenk S
AD  - School of Psychology, Victoria University of Wellington, P.O. Box 600, 
      Wellington, New Zealand. susan.schenk@vuw.ac.nz
FAU - Abraham, Blaine
AU  - Abraham B
FAU - Aronsen, Dane
AU  - Aronsen D
FAU - Colussi-Mas, Joyce
AU  - Colussi-Mas J
FAU - Do, Jennifer
AU  - Do J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130125
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Autoreceptors)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 333DO1RDJY (Serotonin)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
RN  - C1LJO185Q9 (5-Hydroxytryptophan)
RN  - EC 1.14.16.4 (Tryptophan Hydroxylase)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 5-Hydroxytryptophan/metabolism
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/administration & dosage/*pharmacology
MH  - Animals
MH  - Autoreceptors/drug effects/metabolism
MH  - Behavior, Animal/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Serotonin, 5-HT1A/*drug effects/metabolism
MH  - Serotonin/metabolism
MH  - Serotonin Receptor Agonists/administration & dosage/*pharmacology
MH  - Tryptophan Hydroxylase/metabolism
EDAT- 2013/01/29 06:00
MHDA- 2013/10/29 06:00
CRDT- 2013/01/29 06:00
PHST- 2012/09/04 00:00 [received]
PHST- 2012/12/20 00:00 [accepted]
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2013/10/29 06:00 [medline]
AID - 10.1007/s00213-013-2980-5 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2013 May;227(2):355-61. doi: 
      10.1007/s00213-013-2980-5. Epub 2013 Jan 25.