PMID- 23355077
OWN - NLM
STAT- MEDLINE
DCOM- 20140211
LR  - 20220408
IS  - 1468-2060 (Electronic)
IS  - 0003-4967 (Linking)
VI  - 73
IP  - 1
DP  - 2014 Jan
TI  - The characterisation and determinants of quality of life in ANCA associated 
      vasculitis.
PG  - 207-11
LID - 10.1136/annrheumdis-2012-202750 [doi]
AB  - OBJECTIVES: To contextualise and identify the determinants of poor health related 
      quality of life (QOL) among patients with antineutrophil cytoplasm antibody 
      (ANCA) associated vasculitis (AAV). METHODS: A multicentre AAV case-control study 
      was conducted using two matched groups of population and chronic disease 
      controls. Measures of physical and mental QOL as well as putative 
      bio-psychosocial determinants of QOL impairment were collected. Concurrently, 
      putative clinical QOL determinants were recorded. Conditional logistic regression 
      analyses characterised group differences while multivariable logistic regression 
      identified within-case QOL associations which were further quantified using 
      population attributable risks (PAR). RESULTS: Cases (n=410) experienced similar 
      QOL to chronic disease controls (n=318) (physical QOL: OR 0.7, 95% CI 0.4 to 1.1; 
      mental QOL: OR 1.1, 95% CI 0.8 to 1.6). However, they were substantially more 
      likely to report poor QOL compared to general population controls (n=470) 
      (physical QOL: OR 7.0, 95% CI 4.4 to 11.1; mental QOL: OR 2.5, 95% CI 1.7 to 
      3.6). A few clinical, but many more bio-psychosocial factors were independently 
      associated with poor QOL. In population terms, fatigue was found to be of 
      principal importance (physical QOL: PAR 24.6%; mental QOL: PAR 47.4%). 
      CONCLUSIONS: AAV patients experienced significant QOL impairment compared to the 
      general population, but similar to those with other chronic diseases whose 
      considerable needs are already recognised. Potentially modifiable clinical 
      determinants have been identified; however bio-psychosocial interventions are 
      likely to provide the greater QOL gains in this patient population.
FAU - Basu, Neil
AU  - Basu N
AD  - Musculoskeletal Collaboration, School of Medicine and Dentistry, University of 
      Aberdeen, , Aberdeen, UK.
FAU - McClean, Andrew
AU  - McClean A
FAU - Harper, Lorraine
AU  - Harper L
FAU - Amft, Esther Nicole
AU  - Amft EN
FAU - Dhaun, Neeraj
AU  - Dhaun N
FAU - Luqmani, Raashid A
AU  - Luqmani RA
FAU - Little, Mark A
AU  - Little MA
FAU - Jayne, David Rw
AU  - Jayne DR
FAU - Flossmann, Oliver
AU  - Flossmann O
FAU - McLaren, John
AU  - McLaren J
FAU - Kumar, Vinod
AU  - Kumar V
FAU - Erwig, Lars P
AU  - Erwig LP
FAU - Reid, David M
AU  - Reid DM
FAU - Jones, Gareth T
AU  - Jones GT
FAU - Macfarlane, Gary J
AU  - Macfarlane GJ
LA  - eng
GR  - CAF/08/08/CSO_/Chief Scientist Office/United Kingdom
GR  - FS/13/30/29994/BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20130125
PL  - England
TA  - Ann Rheum Dis
JT  - Annals of the rheumatic diseases
JID - 0372355
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/epidemiology/immunology/psychology
MH  - Antibodies, Antineutrophil Cytoplasmic/*immunology
MH  - Anxiety/epidemiology
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Depression/epidemiology
MH  - Fatigue/epidemiology
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - *Quality of Life
MH  - Risk Factors
MH  - Sleep Wake Disorders/epidemiology
MH  - *Surveys and Questionnaires
OTO - NOTNLM
OT  - Granulomatosis with Polyangiitis
OT  - Outcomes Research
OT  - Systemic Vasculitis
EDAT- 2013/01/29 06:00
MHDA- 2014/02/12 06:00
CRDT- 2013/01/29 06:00
PHST- 2013/01/29 06:00 [entrez]
PHST- 2013/01/29 06:00 [pubmed]
PHST- 2014/02/12 06:00 [medline]
AID - annrheumdis-2012-202750 [pii]
AID - 10.1136/annrheumdis-2012-202750 [doi]
PST - ppublish
SO  - Ann Rheum Dis. 2014 Jan;73(1):207-11. doi: 10.1136/annrheumdis-2012-202750. Epub 
      2013 Jan 25.