PMID- 23357749
OWN - NLM
STAT- MEDLINE
DCOM- 20130722
LR  - 20221207
IS  - 1873-3778 (Electronic)
IS  - 0021-9673 (Linking)
VI  - 1280
DP  - 2013 Mar 8
TI  - On-line solid phase extraction-liquid chromatography-tandem mass spectrometry for 
      the determination of 17 cytostatics and metabolites in waste, surface and ground 
      water samples.
PG  - 64-74
LID - S0021-9673(13)00102-7 [pii]
LID - 10.1016/j.chroma.2013.01.031 [doi]
AB  - A fully automated on-line solid-phase extraction-liquid chromatography-tandem 
      mass spectrometry (SPE-LC-MS/MS) method has been developed for the determination 
      of 13 cytostatics and 4 metabolites in aqueous matrices, including groundwater, 
      surface water, and raw and treated wastewater. On-line SPE is performed by 
      loading 5 mL of water sample at pH 2 through a PLRP-s cartridge. MS/MS is 
      performed with an electrospray (ESI) interface operating in the positive ion mode 
      and registering two selected reaction monitoring (SRM) transitions per compound. 
      Quantification is carried out by the isotope dilution method using 15 different 
      isotope-labelled compounds, specific for the target analytes, as internal 
      standards (IS). The main advantages of the method are high sensitivity, with 
      limits of determination in groundwater, surface water, and raw and treated 
      wastewater below 5 ng L(-1) for all compounds except for gemcitabine (6.9-9.3 ng 
      L(-1)), temozolomide (26-50 ng L(-1)), imatinib (80-180 ng L(-1)) and etoposide 
      (38-65 ng L(-1)), repeatability, with relative standard deviations (RSDs) in most 
      cases below 15%, and selectivity and reliability of results. The method is also 
      fairly simple and fast, with an analysis time per sample (excluding the manual 
      steps, i.e., sample filtration, pH adjustment, and addition of IS) of 40 min. 
      Application of the method to influent wastewater samples collected daily during 
      eight consecutive days from a wastewater treatment plant (WWTP) from Catalonia 
      showed the presence of methotrexate, ifosfamide, capecitabine, tamoxifen and 
      6(alpha)-hydroxypaclitaxel but at fairly low concentrations (up to 43 ng L(-1)).
CI  - Copyright (c) 2013 Elsevier B.V. All rights reserved.
FAU - Negreira, Noelia
AU  - Negreira N
AD  - Department of Environmental Chemistry, Institute of Environmental Assessment and 
      Water Research (IDAEA-CSIC), Jordi Girona 18-26, E-08034 Barcelona, Spain.
FAU - Lopez de Alda, Miren
AU  - Lopez de Alda M
FAU - Barcelo, Damia
AU  - Barcelo D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130114
PL  - Netherlands
TA  - J Chromatogr A
JT  - Journal of chromatography. A
JID - 9318488
RN  - 0 (Cytostatic Agents)
RN  - 0 (Waste Water)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Cytostatic Agents/*analysis/chemistry/isolation & purification
MH  - Groundwater/chemistry
MH  - Limit of Detection
MH  - Linear Models
MH  - Reproducibility of Results
MH  - Solid Phase Extraction/*methods
MH  - Spain
MH  - Tandem Mass Spectrometry/*methods
MH  - Wastewater/chemistry
MH  - Water Pollutants, Chemical/*analysis/chemistry/isolation & purification
EDAT- 2013/01/30 06:00
MHDA- 2013/07/23 06:00
CRDT- 2013/01/30 06:00
PHST- 2012/11/09 00:00 [received]
PHST- 2013/01/04 00:00 [revised]
PHST- 2013/01/07 00:00 [accepted]
PHST- 2013/01/30 06:00 [entrez]
PHST- 2013/01/30 06:00 [pubmed]
PHST- 2013/07/23 06:00 [medline]
AID - S0021-9673(13)00102-7 [pii]
AID - 10.1016/j.chroma.2013.01.031 [doi]
PST - ppublish
SO  - J Chromatogr A. 2013 Mar 8;1280:64-74. doi: 10.1016/j.chroma.2013.01.031. Epub 
      2013 Jan 14.