PMID- 23359110
OWN - NLM
STAT- MEDLINE
DCOM- 20130819
LR  - 20220317
IS  - 2157-1422 (Electronic)
IS  - 2157-1422 (Linking)
VI  - 3
IP  - 3
DP  - 2013 Mar 1
TI  - Epigenetics and psychostimulant addiction.
PG  - a012047
LID - 10.1101/cshperspect.a012047 [doi]
LID - a012047
AB  - Chronic drug exposure alters gene expression in the brain and produces long-term 
      changes in neural networks that underlie compulsive drug taking and seeking. 
      Exactly how drug-induced changes in synaptic plasticity and subsequent gene 
      expression are translated into persistent neuroadaptations remains unclear. 
      Emerging evidence suggests that complex drug-induced neuroadaptations in the 
      brain are mediated by highly synchronized and dynamic patterns of gene 
      regulation. Recently, it has become clear that epigenetic mechanisms contribute 
      to drug-induced structural, synaptic, and behavioral plasticity by regulating 
      expression of gene networks. Here we review how alterations in histone 
      modifications, DNA methylation, and microRNAs regulate gene expression and 
      contribute to psychostimulant addiction with a focus on the epigenetic mechanisms 
      that regulate brain-derived neurotrophic factor (BDNF) expression following 
      chronic cocaine exposure. Identifying epigenetic signatures that define 
      psychostimulant addiction may lead to novel, efficacious treatments for drug 
      craving and relapse.
FAU - Schmidt, Heath D
AU  - Schmidt HD
AD  - Department of Psychiatry, University of Pennsylvania School of Medicine, 
      Philadelphia, PA 19104, USA. hschmidt@mail.med.upenn.edu
FAU - McGinty, Jacqueline F
AU  - McGinty JF
FAU - West, Anne E
AU  - West AE
FAU - Sadri-Vakili, Ghazaleh
AU  - Sadri-Vakili G
LA  - eng
GR  - R01 DA003982/DA/NIDA NIH HHS/United States
GR  - R01 DA022202/DA/NIDA NIH HHS/United States
GR  - R01 DA022339/DA/NIDA NIH HHS/United States
GR  - P50-DA15369/DA/NIDA NIH HHS/United States
GR  - K01 DA030445/DA/NIDA NIH HHS/United States
GR  - R01-DA03982/DA/NIDA NIH HHS/United States
GR  - DA022339/DA/NIDA NIH HHS/United States
GR  - NS063953/NS/NINDS NIH HHS/United States
GR  - R01 DA033610/DA/NIDA NIH HHS/United States
GR  - P50 DA015369/DA/NIDA NIH HHS/United States
GR  - U01 NS063953/NS/NINDS NIH HHS/United States
GR  - R01-DA022202/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20130301
PL  - United States
TA  - Cold Spring Harb Perspect Med
JT  - Cold Spring Harbor perspectives in medicine
JID - 101571139
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Chromatin)
RN  - 0 (Histones)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Acetylation/drug effects
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - *Central Nervous System Stimulants
MH  - Chromatin/chemistry/genetics
MH  - Cocaine-Related Disorders/genetics
MH  - DNA Methylation/drug effects
MH  - *Epigenomics
MH  - Genome-Wide Association Study
MH  - Histones/metabolism
MH  - Humans
MH  - Methylation/drug effects
MH  - MicroRNAs/genetics
MH  - Substance-Related Disorders/*genetics
MH  - Transcription, Genetic/genetics
PMC - PMC3579203
EDAT- 2013/01/30 06:00
MHDA- 2013/08/21 06:00
PMCR- 2015/03/01
CRDT- 2013/01/30 06:00
PHST- 2013/01/30 06:00 [entrez]
PHST- 2013/01/30 06:00 [pubmed]
PHST- 2013/08/21 06:00 [medline]
PHST- 2015/03/01 00:00 [pmc-release]
AID - cshperspect.a012047 [pii]
AID - a012047 [pii]
AID - 10.1101/cshperspect.a012047 [doi]
PST - epublish
SO  - Cold Spring Harb Perspect Med. 2013 Mar 1;3(3):a012047. doi: 
      10.1101/cshperspect.a012047.