PMID- 23360680
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20140624
LR  - 20211021
IS  - 1756-994X (Print)
IS  - 1756-994X (Electronic)
IS  - 1756-994X (Linking)
VI  - 5
IP  - 1
DP  - 2013
TI  - Pharmacogenomics of adverse drug reactions.
PG  - 5
LID - 10.1186/gm409 [doi]
AB  - Considerable progress has been made in identifying genetic risk factors for 
      idiosyncratic adverse drug reactions in the past 30 years. These reactions can 
      affect various tissues and organs, including liver, skin, muscle and heart, in a 
      drug-dependent manner. Using both candidate gene and genome-wide association 
      studies, various genes that make contributions of varying extents to each of 
      these forms of reactions have been identified. Many of the associations 
      identified for reactions affecting the liver and skin involve human leukocyte 
      antigen (HLA) genes and for reactions relating to the drugs abacavir and 
      carbamazepine, HLA genotyping is now in routine use prior to drug prescription. 
      Other HLA associations are not sufficiently specific for translation but are 
      still of interest in relation to underlying mechanisms for the reactions. 
      Progress on non-HLA genes affecting adverse drug reactions has been less, but 
      some important associations, such as those of SLCO1B1 and statin myopathy, KCNE1 
      and drug-induced QT prolongation and NAT2 and isoniazid-induced liver injury, are 
      considered. Future prospects for identification of additional genetic risk 
      factors for the various adverse drug reactions are discussed.
FAU - Daly, Ann K
AU  - Daly AK
AD  - Institute of Cellular Medicine, Newcastle University, Medical School, Framlington 
      Place, Newcastle upon Tyne NE2 4HH, UK.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20130129
PL  - England
TA  - Genome Med
JT  - Genome medicine
JID - 101475844
PMC - PMC3707028
EDAT- 2013/01/31 06:00
MHDA- 2013/01/31 06:01
PMCR- 2014/01/29
CRDT- 2013/01/31 06:00
PHST- 2013/01/31 06:00 [entrez]
PHST- 2013/01/31 06:00 [pubmed]
PHST- 2013/01/31 06:01 [medline]
PHST- 2014/01/29 00:00 [pmc-release]
AID - gm409 [pii]
AID - 10.1186/gm409 [doi]
PST - epublish
SO  - Genome Med. 2013 Jan 29;5(1):5. doi: 10.1186/gm409. eCollection 2013.