PMID- 23360883
OWN - NLM
STAT- MEDLINE
DCOM- 20130403
LR  - 20130130
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 109 Suppl 2
DP  - 2013 Jan
TI  - Host genotype, intestinal microbiota and inflammatory disorders.
PG  - S76-80
LID - 10.1017/S0007114512005521 [doi]
AB  - Intestinal microbiota may influence human physiology and disease risk due to the 
      role it plays in mediating appropriate immune responses to harmful and innocuous 
      antigens. Colonisation of the intestine in early life seems particularly 
      important as it is the main environmental stimulus for immune system maturation. 
      This is a dynamic process, which depends on both environmental and genetic 
      factors. The pathogenesis of inflammatory bowel disease, such as Crohn's disease, 
      involves genetic polymorphisms (e.g. CARD15/nucleotide-binding oligomerisation 
      domain 2) related to an excessive inflammatory response to commensal microbiota 
      and to its unbalanced composition. Atopic diseases have also been linked to 
      imbalances in microbiota and to related genetic factors (e.g. TLR4 and CD14 
      genes), although these associations are still controversial. Research into the 
      relationship between the genetic risk of developing celiac disease (human 
      leukocyte antigen (HLA)-DQ2/DQ8) and the early colonisation process in infants at 
      family risk of the disease has also reported that the HLA-DQ genotype could 
      influence staphylococcal colonisation. Future observational studies considering 
      both host genetics and microbiota could be critical in defining the complex 
      host-microbe interactions and the respective role each plays in inflammatory 
      disorders.
FAU - Olivares, Marta
AU  - Olivares M
AD  - Microbial Ecology and Nutrition Research Group, Institute of Agrochemistry and 
      Food Technology, National Research Council (IATA-CSIC), Avenida Agustin 
      Escardino, 7. 46980 Paterna, Valencia, Spain.
FAU - Laparra, J Moises
AU  - Laparra JM
FAU - Sanz, Yolanda
AU  - Sanz Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ2 antigen)
RN  - 0 (HLA-DQ8 antigen)
RN  - 0 (NOD2 protein, human)
RN  - 0 (Nod2 Signaling Adaptor Protein)
SB  - IM
MH  - Animals
MH  - Celiac Disease/genetics/immunology/metabolism/microbiology
MH  - Enterocolitis/*genetics/immunology/metabolism/*microbiology
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ Antigens/genetics/metabolism
MH  - *Host-Parasite Interactions
MH  - Host-Pathogen Interactions
MH  - Humans
MH  - Inflammatory Bowel Diseases/genetics/immunology/metabolism/microbiology
MH  - Intestinal Diseases/*genetics/immunology/metabolism/*microbiology
MH  - Intestinal Mucosa/immunology/metabolism/*microbiology
MH  - Nod2 Signaling Adaptor Protein/genetics/metabolism
EDAT- 2013/02/13 06:00
MHDA- 2013/04/04 06:00
CRDT- 2013/01/31 06:00
PHST- 2013/01/31 06:00 [entrez]
PHST- 2013/02/13 06:00 [pubmed]
PHST- 2013/04/04 06:00 [medline]
AID - S0007114512005521 [pii]
AID - 10.1017/S0007114512005521 [doi]
PST - ppublish
SO  - Br J Nutr. 2013 Jan;109 Suppl 2:S76-80. doi: 10.1017/S0007114512005521.