PMID- 23361612
OWN - NLM
STAT- MEDLINE
DCOM- 20130415
LR  - 20220311
IS  - 1535-7228 (Electronic)
IS  - 0002-953X (Print)
IS  - 0002-953X (Linking)
VI  - 170
IP  - 3
DP  - 2013 Mar
TI  - Abnormalities of dorsolateral prefrontal function in women with premenstrual 
      dysphoric disorder: a multimodal neuroimaging study.
PG  - 305-14
LID - 10.1176/appi.ajp.2012.12030385 [doi]
AB  - OBJECTIVE: To investigate the neural substrate of premenstrual dysphoric disorder 
      (PMDD), the authors used [15O]H2O positron emission tomography (PET) regional 
      cerebral blood flow (rCBF) and blood-oxygen-level-dependent (BOLD) functional MRI 
      (fMRI) signal measurements during working memory in conjunction with a 6-month 
      hormone manipulation protocol. METHOD: PET and fMRI scans were obtained from 
      women with prospectively confirmed PMDD and asymptomatic comparison subjects 
      while they completed the n-back task during three hormone conditions: ovarian 
      suppression induced by the gonadotropin-releasing hormone agonist leuprolide 
      acetate, leuprolide plus estradiol, and leuprolide plus progesterone. Fifteen 
      patients and 15 matched comparison subjects underwent PET imaging. Fourteen 
      patients and 14 comparison subjects underwent fMRI. For each hormone condition, 
      rCBF was measured with [15O]H2O PET, and BOLD signal was measured with fMRI, both 
      during an n-back working memory paradigm. Global Assessment of Functioning Scale 
      (GAF) scores and clinical characteristics were obtained for each patient before 
      hormone manipulation, and symptoms were measured before and during the protocol. 
      RESULTS: In both the PET and fMRI studies, a main effect of diagnosis was 
      observed, with PMDD patients showing greater prefrontal activation than 
      comparison subjects. In the patient group, the degree to which dorsolateral 
      prefrontal cortex activation was abnormally increased correlated with several 
      dimensions of disease: disability as indicated by GAF scores, age at symptom 
      onset, duration of PMDD, and differences in pre- and postmenses PMDD symptoms. 
      CONCLUSIONS: Abnormal working memory activation in PMDD, specifically in the 
      dorsolateral prefrontal cortex, is related to PMDD severity, symptoms, age at 
      onset, and disease burden. These results support the clinical relevance of the 
      findings and the proposal that dorsolateral prefrontal cortex dysfunction 
      represents a substrate of risk for PMDD. The concordance of the fMRI and PET data 
      attests to the neurobiological validity of the results.
FAU - Baller, Erica B
AU  - Baller EB
AD  - Section on Integrative Neuroimaging, Clinical Brain Disorders Branch, Gene, 
      Cognition, NIMH Intramural Research Programs, NIH, Bethesda, MD, USA.
FAU - Wei, Shau-Ming
AU  - Wei SM
FAU - Kohn, Philip D
AU  - Kohn PD
FAU - Rubinow, David R
AU  - Rubinow DR
FAU - Alarcon, Gabriela
AU  - Alarcon G
FAU - Schmidt, Peter J
AU  - Schmidt PJ
FAU - Berman, Karen F
AU  - Berman KF
LA  - eng
GR  - ZIA MH002865-08/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Review
PL  - United States
TA  - Am J Psychiatry
JT  - The American journal of psychiatry
JID - 0370512
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - EFY6W0M8TG (Leuprolide)
RN  - S88TT14065 (Oxygen)
SB  - IM
CIN - Am J Psychiatry. 2013 Mar;170(3):248-52. PMID: 23450284
MH  - Adult
MH  - Brain Mapping
MH  - Drug Therapy, Combination
MH  - Estradiol/therapeutic use
MH  - Female
MH  - Humans
MH  - *Image Processing, Computer-Assisted
MH  - *Imaging, Three-Dimensional
MH  - Leuprolide/therapeutic use
MH  - *Magnetic Resonance Imaging
MH  - Memory, Short-Term/drug effects/*physiology
MH  - Oxygen/*blood
MH  - *Positron-Emission Tomography
MH  - Prefrontal Cortex/blood supply/drug effects/*physiopathology
MH  - Premenstrual Syndrome/drug therapy/*physiopathology/psychology
MH  - Progesterone/therapeutic use
MH  - Prospective Studies
PMC - PMC3968942
MID - NIHMS557512
COIS- The authors report no financial relationships with commercial interests.
EDAT- 2013/01/31 06:00
MHDA- 2013/04/16 06:00
PMCR- 2014/03/28
CRDT- 2013/01/31 06:00
PHST- 2013/01/31 06:00 [entrez]
PHST- 2013/01/31 06:00 [pubmed]
PHST- 2013/04/16 06:00 [medline]
PHST- 2014/03/28 00:00 [pmc-release]
AID - 1566973 [pii]
AID - 10.1176/appi.ajp.2012.12030385 [doi]
PST - ppublish
SO  - Am J Psychiatry. 2013 Mar;170(3):305-14. doi: 10.1176/appi.ajp.2012.12030385.