PMID- 23361938
OWN - NLM
STAT- MEDLINE
DCOM- 20130805
LR  - 20161125
IS  - 1097-4547 (Electronic)
IS  - 0360-4012 (Linking)
VI  - 91
IP  - 4
DP  - 2013 Apr
TI  - Effects of chronic caffeine intake in a mouse model of amyotrophic lateral 
      sclerosis.
PG  - 585-92
LID - 10.1002/jnr.23185 [doi]
AB  - Caffeine is a nonselective adenosine receptor antagonist; chronic consumption has 
      proved protective toward neurodegenerative diseases such as Parkinson's and 
      Alzheimer's diseases. The present study was designed to determine whether 
      caffeine intake affected survival and/or motor performance in a transgenic model 
      of amyotrophic lateral sclerosis (ALS). SOD1(G93A) mice received caffeine through 
      drinking water from 70 days of age until death. Body weight, motor performance 
      and survival were evaluated. Furthermore, the expression of adenosine A(2A) 
      receptors (A(2A) Rs), glial glutamate transporter (GLT1), and glial fibrillar 
      acidic protein (GFAP) were evaluated by Western blotting. The results showed that 
      caffeine intake significantly shortened the survival of SOD1(G93A) mice (log rank 
      test, P = 0.01) and induced a nonsignificant advancing of disease onset. The 
      expression of A(2A) R, GLT1, and GFAP was altered in the spinal cords of ALS 
      mice, but caffeine did not influence their expression in either wild-type or 
      SOD1(G93) mice. These data indicate that adenosine receptors may play an 
      important role in ALS.
CI  - Copyright (c) 2013 Wiley Periodicals, Inc.
FAU - Potenza, Rosa Luisa
AU  - Potenza RL
AD  - Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore 
      di Sanita, Rome, Italy. rosa.potenza@iss.it
FAU - Armida, Monica
AU  - Armida M
FAU - Ferrante, Antonella
AU  - Ferrante A
FAU - Pezzola, Antonella
AU  - Pezzola A
FAU - Matteucci, Alessandra
AU  - Matteucci A
FAU - Puopolo, Maria
AU  - Puopolo M
FAU - Popoli, Patrizia
AU  - Popoli P
LA  - eng
PT  - Journal Article
DEP - 20130130
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Receptor, Adenosine A2A)
RN  - 3G6A5W338E (Caffeine)
RN  - EC 1.15.1.1 (Sod1 protein, mouse)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 1.15.1.1 (Superoxide Dismutase-1)
SB  - IM
MH  - Administration, Oral
MH  - Amyotrophic Lateral Sclerosis/genetics/*metabolism
MH  - Animals
MH  - Body Weight/drug effects/physiology
MH  - Caffeine/*administration & dosage
MH  - Disease Models, Animal
MH  - Longevity/*drug effects
MH  - Mice
MH  - Mice, Transgenic
MH  - Motor Neurons/*drug effects/metabolism
MH  - Motor Skills/*drug effects
MH  - Receptor, Adenosine A2A/metabolism
MH  - Rotarod Performance Test
MH  - Spinal Cord/*drug effects/metabolism
MH  - Superoxide Dismutase/genetics/metabolism
MH  - Superoxide Dismutase-1
EDAT- 2013/01/31 06:00
MHDA- 2013/08/06 06:00
CRDT- 2013/01/31 06:00
PHST- 2012/06/21 00:00 [received]
PHST- 2012/10/29 00:00 [revised]
PHST- 2012/11/01 00:00 [accepted]
PHST- 2013/01/31 06:00 [entrez]
PHST- 2013/01/31 06:00 [pubmed]
PHST- 2013/08/06 06:00 [medline]
AID - 10.1002/jnr.23185 [doi]
PST - ppublish
SO  - J Neurosci Res. 2013 Apr;91(4):585-92. doi: 10.1002/jnr.23185. Epub 2013 Jan 30.