PMID- 23362074
OWN - NLM
STAT- MEDLINE
DCOM- 20130916
LR  - 20211021
IS  - 1757-790X (Electronic)
IS  - 1757-790X (Linking)
VI  - 2013
DP  - 2013 Jan 28
TI  - Penicillium marneffei presenting as an immune reconstitution inflammatory 
      syndrome (IRIS) in a patient with advanced HIV.
LID - 10.1136/bcr-2012-007555 [doi]
LID - bcr2012007555
AB  - A 62-year-old British man with advanced HIV was established on antiretroviral 
      therapy and treatment for disseminated Mycobacterium avium complex and 
      Cytomegalovirus infections. One month later he re-presented with epigastric pain, 
      an epigastric mass and skin lesions. Abdominal imaging revealed large volume 
      lymphadenopathy, which was not present on previous imaging. Blood cultures 
      yielded Penicillium marneffei, a dimorphic fungus endemic to South-east Asia. The 
      patient had spent several years travelling in Thailand prior to the diagnosis of 
      HIV. Penicilliosis is a common AIDS-defining illness in endemic areas, but 
      remains rare in Europe. In this case, it presented in the context of a rapidly 
      decreasing viral load as an immune reconstitution inflammatory syndrome. The 
      challenges of management in the context of multiple comorbidities and 
      polypharmacy are discussed.
FAU - Hall, Charlotte
AU  - Hall C
AD  - Department of Infection and Tropical Medicine, Hull and East Yorkshire NHS Trust, 
      Cottingham, East Riding of Yorkshire, UK. charlotteamyhall@gmail.com
FAU - Hajjawi, Rachel
AU  - Hajjawi R
FAU - Barlow, Gavin
AU  - Barlow G
FAU - Thaker, Hiten
AU  - Thaker H
FAU - Adams, Kate
AU  - Adams K
FAU - Moss, Peter
AU  - Moss P
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20130128
PL  - England
TA  - BMJ Case Rep
JT  - BMJ case reports
JID - 101526291
RN  - 0 (Antifungal Agents)
SB  - IM
MH  - Antifungal Agents/therapeutic use
MH  - Diagnosis, Differential
MH  - HIV Infections/*complications/microbiology
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*diagnosis
MH  - Lymphatic Diseases/etiology
MH  - Male
MH  - Middle Aged
MH  - Mycoses/*diagnosis/drug therapy/etiology
MH  - *Penicillium
MH  - Splenomegaly/etiology
PMC - PMC3604501
EDAT- 2013/01/31 06:00
MHDA- 2013/09/17 06:00
PMCR- 2015/01/28
CRDT- 2013/01/31 06:00
PHST- 2013/01/31 06:00 [entrez]
PHST- 2013/01/31 06:00 [pubmed]
PHST- 2013/09/17 06:00 [medline]
PHST- 2015/01/28 00:00 [pmc-release]
AID - bcr-2012-007555 [pii]
AID - 10.1136/bcr-2012-007555 [doi]
PST - epublish
SO  - BMJ Case Rep. 2013 Jan 28;2013:bcr2012007555. doi: 10.1136/bcr-2012-007555.