PMID- 23362142
OWN - NLM
STAT- MEDLINE
DCOM- 20130829
LR  - 20131121
IS  - 1531-2267 (Electronic)
IS  - 1094-8341 (Linking)
VI  - 45
IP  - 6
DP  - 2013 Mar 18
TI  - Higher cardiorespiratory fitness attenuates arterial stiffening associated with 
      the Ala54Thr polymorphism in FABP2.
PG  - 237-42
LID - 10.1152/physiolgenomics.00089.2012 [doi]
AB  - Fatty acid binding protein 2 (FABP2) Ala54Thr polymorphism is a candidate gene 
      associated with the risk of cardiovascular disease. Habitual exercise brings 
      higher cardiorespiratory fitness and results in the improvement of cardiovascular 
      disease risk. However, the effect of cardiorespiratory fitness level and FABP2 
      Ala54Thr polymorphism on the risk of cardiovascular diseases remains unclear. In 
      the present study, a cross-sectional investigation of 837 Japanese men and women 
      was performed to clarify the effects of cardiorespiratory fitness on the 
      relationship between risk of cardiovascular disease and FABP2 Ala54Thr gene 
      polymorphism. The study subjects were divided into high-cardiorespiratory fitness 
      (High-Fit) and low-cardiorespiratory fitness (Low-Fit) groups based on the median 
      value of peak oxygen uptake in each sex and decade. The FABP2 Ala54Thr 
      polymorphism did not significantly affect carotid beta-stiffness or blood pressure. 
      In the Low-Fit group, carotid beta-stiffness, systolic blood pressure, and diastolic 
      blood pressure were higher for individuals with the Ala/Ala genotype compared 
      with those with the Ala/Thr or Thr/Thr genotype, whereas no differences were 
      observed in the High-Fit group. Additionally, serum triglyceride and plasma 
      glucose levels were lower and serum high-density lipoprotein cholesterol levels 
      were higher in the High-Fit group compared with the Low-Fit group; the FABP2 
      Ala54Thr polymorphism did not significantly affect these parameters. These 
      results suggest that the higher cardiorespiratory fitness may attenuate the 
      changes in central arterial stiffness and blood pressure that are associated with 
      the FABP2 genotype.
FAU - Fujie, Shumpei
AU  - Fujie S
AD  - Faculty of Sport and Health Science, Ritsumeikan University, Shiga, Japan.
FAU - Iemitsu, Motoyuki
AU  - Iemitsu M
FAU - Murakami, Haruka
AU  - Murakami H
FAU - Sanada, Kiyoshi
AU  - Sanada K
FAU - Kawano, Hiroshi
AU  - Kawano H
FAU - Gando, Yuko
AU  - Gando Y
FAU - Kawakami, Ryoko
AU  - Kawakami R
FAU - Miyachi, Motohiko
AU  - Miyachi M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130129
PL  - United States
TA  - Physiol Genomics
JT  - Physiological genomics
JID - 9815683
RN  - 0 (DNA Primers)
RN  - 0 (FABP2 protein, human)
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 2ZD004190S (Threonine)
RN  - OF5P57N2ZX (Alanine)
SB  - IM
MH  - Adult
MH  - Alanine/*genetics
MH  - Arteries/*physiopathology
MH  - Base Sequence
MH  - *Cardiovascular Physiological Phenomena
MH  - Cross-Sectional Studies
MH  - DNA Primers
MH  - Fatty Acid-Binding Proteins/*genetics
MH  - Female
MH  - Humans
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Real-Time Polymerase Chain Reaction
MH  - *Respiratory Physiological Phenomena
MH  - Threonine/*genetics
EDAT- 2013/01/31 06:00
MHDA- 2013/08/30 06:00
CRDT- 2013/01/31 06:00
PHST- 2013/01/31 06:00 [entrez]
PHST- 2013/01/31 06:00 [pubmed]
PHST- 2013/08/30 06:00 [medline]
AID - physiolgenomics.00089.2012 [pii]
AID - 10.1152/physiolgenomics.00089.2012 [doi]
PST - ppublish
SO  - Physiol Genomics. 2013 Mar 18;45(6):237-42. doi: 
      10.1152/physiolgenomics.00089.2012. Epub 2013 Jan 29.