PMID- 23362831
OWN - NLM
STAT- MEDLINE
DCOM- 20140820
LR  - 20131216
IS  - 1748-1716 (Electronic)
IS  - 1748-1708 (Linking)
VI  - 210
IP  - 1
DP  - 2014 Jan
TI  - Differential developmental programming by early protein restriction of rat 
      skeletal muscle according to its fibre-type composition.
PG  - 70-83
LID - 10.1111/apha.12073 [doi]
AB  - AIMS: Differences in fibre-type composition of skeletal muscle have been 
      associated with obesity and insulin resistance. As a poor nutrient environment 
      early in life is a predisposing factor for the development of obesity and related 
      metabolic diseases at adulthood, this study aimed at determining the long-term 
      consequences of maternal undernutrition on the structural and metabolic 
      properties of two skeletal muscles characterized by their different fibre-type 
      composition and metabolic properties. METHODS: The fibre-type composition and 
      enzymatic activities of hexokinase (HK), beta-hydroxyacyl-CoA dehydrogenase 
      (beta-HAD) and citrate synthase (CS) were measured in soleus and extensor digitorum 
      longus (EDL) muscles from adult rats born to dams fed a control (17% protein) or 
      a low-protein [8% protein (PR)] diet throughout pregnancy and lactation. In 
      addition, the expression levels of several genes regulating glycolysis, fatty 
      acid oxidation and mitochondrial biogenesis were determined by real-time PCR. 
      RESULTS: Protein rats exhibited enhanced density of type II fibres along with 
      decreased rate of fatty acid oxidation and glycolysis in soleus but not EDL. 
      Malnourished rats exhibited also a different gene expression profile in soleus 
      and EDL. Altogether, these alterations correspond to a state of energy deficiency 
      and are present in animals which do not show yet any sign of obesity or glucose 
      intolerance. CONCLUSION: We conclude that maternal protein restriction alters in 
      the long term the structural and enzymatic properties of offspring skeletal 
      muscle in a fibre-type-dependent manner. These alterations might have a causative 
      role in the development of obesity and related metabolic disorders later in life.
CI  - Acta Physiologica (c) 2013 Scandinavian Physiological Society.
FAU - da Silva Aragao, R
AU  - da Silva Aragao R
AD  - INRA, UMR1280 Physiologie des Adaptations Nutritionnelles, Nantes, France; 
      Universite de Nantes, Nantes Atlantique Universite, Nantes, France; Departamento 
      de Nutricao, Centro de Ciencias da Saude, Universidade Federal de Pernambuco, 
      Recife, Brazil.
FAU - Guzman-Quevedo, O
AU  - Guzman-Quevedo O
FAU - Perez-Garcia, G
AU  - Perez-Garcia G
FAU - Toscano, A E
AU  - Toscano AE
FAU - Gois Leandro, C
AU  - Gois Leandro C
FAU - Manhaes-de-Castro, R
AU  - Manhaes-de-Castro R
FAU - Bolanos-Jimenez, F
AU  - Bolanos-Jimenez F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20130311
PL  - England
TA  - Acta Physiol (Oxf)
JT  - Acta physiologica (Oxford, England)
JID - 101262545
RN  - 0 (Dietary Proteins)
RN  - 0 (Muscle Proteins)
RN  - EC 1.1.1.- (3-Hydroxyacyl CoA Dehydrogenases)
RN  - EC 2.3.3.1 (Citrate (si)-Synthase)
RN  - EC 2.7.1.1 (Hexokinase)
SB  - IM
MH  - 3-Hydroxyacyl CoA Dehydrogenases/metabolism
MH  - Aging/*metabolism/pathology
MH  - Animals
MH  - Citrate (si)-Synthase/metabolism
MH  - *Diet, Protein-Restricted
MH  - Dietary Proteins/metabolism
MH  - Female
MH  - Hexokinase/metabolism
MH  - Male
MH  - Muscle Fibers, Fast-Twitch/*enzymology/*pathology
MH  - Muscle Fibers, Slow-Twitch/*enzymology/*pathology
MH  - Muscle Proteins/*metabolism
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - developmental programming
OT  - metabolism
OT  - skeletal muscle
EDAT- 2013/02/01 06:00
MHDA- 2014/08/21 06:00
CRDT- 2013/02/01 06:00
PHST- 2012/10/05 00:00 [received]
PHST- 2012/11/13 00:00 [revised]
PHST- 2012/12/29 00:00 [revised]
PHST- 2013/01/25 00:00 [accepted]
PHST- 2013/02/01 06:00 [entrez]
PHST- 2013/02/01 06:00 [pubmed]
PHST- 2014/08/21 06:00 [medline]
AID - 10.1111/apha.12073 [doi]
PST - ppublish
SO  - Acta Physiol (Oxf). 2014 Jan;210(1):70-83. doi: 10.1111/apha.12073. Epub 2013 Mar 
      11.