PMID- 23363736
OWN - NLM
STAT- MEDLINE
DCOM- 20131018
LR  - 20130521
IS  - 1423-0097 (Electronic)
IS  - 1018-2438 (Linking)
VI  - 161
IP  - 2
DP  - 2013
TI  - Mild asthma and chronic bronchitis seem to influence functional exercise 
      capacity: a multi-case control study.
PG  - 181-8
LID - 10.1159/000345137 [doi]
AB  - BACKGROUND: In the Genes Environment Interaction in Respiratory Diseases 
      population-based multi-case control study, we investigated whether asthma, 
      chronic bronchitis (CB) and rhinitis were associated with a reduced 6-minute walk 
      distance (6MWD), and whether the 6MWD determinants were similar for subjects 
      with/without respiratory diseases. METHODS: Cases of asthma (n = 360), CB (n = 
      120), rhinitis (n = 203) and controls (no respiratory diseases: n = 302) were 
      recruited. The variation in the 6MWD across the groups was analyzed by ANCOVA, 
      adjusting for gender, age, height, weight and comorbidity. The 6MWD determinants 
      were studied by linear regression, and heterogeneity across the cases and 
      controls was investigated. RESULTS: The 6MWD differed across cases and controls 
      (p = 0.01). It was shorter for cases of asthma (-17.1, 95% CI -28.3 to -5.8 m) 
      and CB (-20.7, 95% CI: -36.6 to -4.8 m) than for controls (604 +/- 68 m on 
      average), but not for cases of rhinitis. The negative association between age and 
      the 6MWD was significant for cases of CB, but not for the other groups (p = 
      0.001). CONCLUSIONS: Even at the level of severity found in the general 
      population, asthma and CB could influence the 6MWD, which seems to reflect the 
      functional exercise level for daily physical activities. The negative association 
      between ageing and the 6MWD was particularly strong in subjects with CB. Our 
      report adds to the mounting evidence that CB is not a trivial condition, 
      especially in the ageing adult population, and it supports the importance of 
      monitoring functional capacity and of physical reconditioning in mild asthma.
CI  - Copyright (c) 2013 S. Karger AG, Basel.
FAU - Marcon, Alessandro
AU  - Marcon A
AD  - Unit of Epidemiology and Medical Statistics, Department of Public Health and 
      Community Medicine, University of Verona, Verona, Italy. 
      alessandro.marcon@univr.it
FAU - Girardi, Paolo
AU  - Girardi P
FAU - Ferrari, Marcello
AU  - Ferrari M
FAU - Olivieri, Mario
AU  - Olivieri M
FAU - Accordini, Simone
AU  - Accordini S
FAU - Bombieri, Cristina
AU  - Bombieri C
FAU - Bortolami, Oscar
AU  - Bortolami O
FAU - Braggion, Marco
AU  - Braggion M
FAU - Cappa, Veronica
AU  - Cappa V
FAU - Cazzoletti, Lucia
AU  - Cazzoletti L
FAU - Locatelli, Francesca
AU  - Locatelli F
FAU - Nicolis, Morena
AU  - Nicolis M
FAU - Perbellini, Luigi
AU  - Perbellini L
FAU - Sembeni, Silvia
AU  - Sembeni S
FAU - Verlato, Giuseppe
AU  - Verlato G
FAU - Zanolin, Maria Elisabetta
AU  - Zanolin ME
FAU - de Marco, Roberto
AU  - de Marco R
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20130124
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Asthma/*physiopathology
MH  - Bronchitis, Chronic/*physiopathology
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Rhinitis/*physiopathology
MH  - Sex Factors
MH  - Young Adult
EDAT- 2013/02/01 06:00
MHDA- 2013/10/19 06:00
CRDT- 2013/02/01 06:00
PHST- 2012/07/06 00:00 [received]
PHST- 2012/10/15 00:00 [accepted]
PHST- 2013/02/01 06:00 [entrez]
PHST- 2013/02/01 06:00 [pubmed]
PHST- 2013/10/19 06:00 [medline]
AID - 000345137 [pii]
AID - 10.1159/000345137 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2013;161(2):181-8. doi: 10.1159/000345137. Epub 2013 
      Jan 24.