PMID- 23363778
OWN - NLM
STAT- Publisher
LR  - 20220310
IS  - 1469-5111 (Electronic)
IS  - 1461-1457 (Linking)
VI  - 16
IP  - 6
DP  - 2013 Jul
TI  - Decreased serum levels of brain-derived neurotrophic factor in adults with 
      attention-deficit hyperactivity disorder.
PG  - 1267-1275
AB  - It has been hypothesized that brain-derived neurotrophic factor (BDNF) is 
      involved in the pathogenesis of attention-deficit hyperactivity disorder (ADHD), 
      although experimental data regarding the contribution of BDNF gene polymorphisms 
      to this psychiatric disorder are controversial. Recently, changes in BDNF serum 
      levels have been reported in children with ADHD, but there are no studies about 
      the possible role of this neurotrophin in adults. A total of 54 Caucasoid ADHD 
      adults, including the predominantly inattentive and combined types (aged 
      33.43 +/- 8.99 yr) and 59 Caucasoid unrelated healthy controls (aged 35.52 +/- 9.37 
      yr) were included in a study to evaluate BDNF levels in serum. Medical, 
      neurological and psychiatric co-morbidities were excluded. Clinical data 
      concerning ADHD diagnosis and blood samples for patients and controls were 
      collected. BDNF serum levels were significantly lower in adults with ADHD 
      compared to healthy controls (p < 0.0001). Although the combined type of ADHD 
      subgroup displayed lower BDNF serum levels than the inattentive type, the 
      differences did not reach statistical significance. No significant correlations 
      were found between serum BDNF levels and scores on the Conners' Adult ADHD Rating 
      Subscales. These results suggest a role for BDNF in ADHD, at least in those 
      patients whose disorder persists throughout life. Low BDNF levels may contribute 
      to the neurodevelopmental deficits of ADHD and to the persistence of the disorder 
      into adulthood. BDNF differences between ADHD subtypes should be further studied.
FAU - Corominas-Roso, Margarida
AU  - Corominas-Roso M
AD  - Department of Psychiatry, Hospital Universitari Vall d'Hebron (UAB), Barcelona, 
      Catalonia, Spain.
FAU - Ramos-Quiroga, Josep A
AU  - Ramos-Quiroga JA
FAU - Ribases, Marta
AU  - Ribases M
FAU - Sanchez-Mora, Cristina
AU  - Sanchez-Mora C
FAU - Palomar, Gloria
AU  - Palomar G
FAU - Valero, Sergi
AU  - Valero S
FAU - Bosch, Rosa
AU  - Bosch R
FAU - Casas, Miguel
AU  - Casas M
LA  - eng
PT  - Journal Article
DEP - 20130130
PL  - England
TA  - Int J Neuropsychopharmacol
JT  - The international journal of neuropsychopharmacology
JID - 9815893
EDAT- 2013/02/01 06:00
MHDA- 2013/02/01 06:00
CRDT- 2013/02/01 06:00
PHST- 2013/02/01 06:00 [entrez]
PHST- 2013/02/01 06:00 [pubmed]
PHST- 2013/02/01 06:00 [medline]
AID - S1461145712001629 [pii]
AID - 10.1017/S1461145712001629 [doi]
PST - ppublish
SO  - Int J Neuropsychopharmacol. 2013 Jul;16(6):1267-1275. doi: 
      10.1017/S1461145712001629. Epub 2013 Jan 30.