PMID- 23363962
OWN - NLM
STAT- MEDLINE
DCOM- 20140811
LR  - 20130131
IS  - 0253-9624 (Print)
IS  - 0253-9624 (Linking)
VI  - 46
IP  - 12
DP  - 2012 Dec
TI  - [Effects of systolic blood pressure and low density lipoprotein on carotid 
      plaques].
PG  - 1074-8
AB  - OBJECTIVE: To explore the different effects of systolic blood pressure (SBP) and 
      low density lipoprotein on carotid plaques (LDL-C). METHODS: A total of 101 510 
      serving and retired workers of a company who participated in the health 
      examination in 2006-2009, 5852 participants were selected as study subjects by 
      stratified random sampling according to the age and sex ratio. These subjects 
      took their health examination in 2010-2011 including the carotid ultrasound. 
      Finally, 5361 eligible participants with complete data were included in the 
      analysis. The detection and weighted rates of carotid plaques were calculated for 
      four groups: normal SBP and LDL-C group (3524 subjects), normal SBP and high 
      LDL-C group (356 subjects), elevated SBP and normal LDL-C group (1308 subjects) 
      and elevated SBP and high LDL-C group (173 subjects). The effects of different 
      baseline SBP and LDL-C on detection rates of the carotid artery plaques were 
      analyzed by logistic regression. RESULTS: The detection rate of carotid plaques 
      in normal SBP and LDL-C group, normal SBP and high LDL-C group, elevated SBP and 
      normal LDL-C group, elevated SBP and high LDL-C group was 33.7% (1186/3524), 
      41.3% (147/356), 64.8% (847/1308), 68.8% (119/173) (chi(2) = 425.75, P < 0.05) and 
      the weighted detection rate was 36.0%, 42.0%, 64.5% and 68.3% respectively. For 
      men, the detection rate was 44.2% (877/1985), 51.1% (97/190), 70.6% (657/930), 
      71.3% (82/115) (chi(2) = 194.02, P < 0.05) and the weighted detection rate was 
      31.2%, 36.1%, 49.8% and 50.3% respectively. For women, the detection rate was 
      20.1% (309/1539), 30.1% (50/166), 50.3% (190/378), 63.8% (37/58) (chi(2) = 180.17, 
      P < 0.05) and the weighted detection rate was 30.9%, 46.3%, 70.3%, and 88.1% 
      respectively. After adjusted for other risk factors, the OR (95%CI) value was 
      1.37 (1.05 - 1.78), 2.05 (1.74 - 2.43) and 2.12 (1.45 - 3.12) for normal SBP and 
      high LDL-C group, elevated SBP and normal LDL-C group and elevated SBP and high 
      LDL-C group respectively compared with normal SBP and LDL-C group. CONCLUSION: 
      Elevated SBP and high LDL-C were risk factors of the carotid artery plaques. 
      Compared with high LDL-C, elevated SBP may add a higher risk for carotid plaques.
FAU - Yao, Tao
AU  - Yao T
AD  - Department of Medicine, Linxi Hospital, Affiliated Kailuan General Hospital, 
      Hebei University, Tangshan 063000, China.
FAU - Li, Wen
AU  - Li W
FAU - Zhang, Xiao-Hui
AU  - Zhang XH
FAU - Sun, Jing
AU  - Sun J
FAU - Wang, De-Sheng
AU  - Wang DS
FAU - Zhao, Yong-Meng
AU  - Zhao YM
FAU - Wang, Zhang-Feng
AU  - Wang ZF
FAU - Zhao, Xing-Quan
AU  - Zhao XQ
FAU - Wu, Shou-Ling
AU  - Wu SL
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - China
TA  - Zhonghua Yu Fang Yi Xue Za Zhi
JT  - Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
JID - 7904962
RN  - 0 (Cholesterol, LDL)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Blood Pressure
MH  - Carotid Stenosis/blood/*epidemiology/physiopathology
MH  - Cholesterol, LDL/*blood
MH  - Dyslipidemias
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Systole
EDAT- 2013/02/01 06:00
MHDA- 2014/08/12 06:00
CRDT- 2013/02/01 06:00
PHST- 2013/02/01 06:00 [entrez]
PHST- 2013/02/01 06:00 [pubmed]
PHST- 2014/08/12 06:00 [medline]
PST - ppublish
SO  - Zhonghua Yu Fang Yi Xue Za Zhi. 2012 Dec;46(12):1074-8.