PMID- 23365400
OWN - NLM
STAT- MEDLINE
DCOM- 20130729
LR  - 20220321
IS  - 1525-3163 (Electronic)
IS  - 0021-8812 (Linking)
VI  - 90 Suppl 4
DP  - 2012 Dec
TI  - Butyrate supplementation to gestating sows and piglets induces muscle and adipose 
      tissue oxidative genes and improves growth performance.
PG  - 430-2
LID - 10.2527/jas.53817 [doi]
AB  - Weaned pigs often experience growth reduction immediately after weaning due to 
      multiple stress factors associated with weaning. We tested the effect of prenatal 
      and postnatal butyrate supplementation on growth performance of piglets. In study 
      1, piglets were orally gavaged with 0.3% butyrate from day 4 after birth to 
      weaning (day 21). Butyrate increased ADG by 13% compared to saline treated 
      control. Expression of peroxisome proliferator activated receptor gamma 
      coactivator 1 alpha (PGC-1alpha) was higher in muscle, adipose tissue, and ileum of 
      butyrate-supplemented animals. Also, peroxisome proliferator activated receptor 
      alpha (PPARalpha) was induced (P < 0.05) in the subcutaneous adipose tissue (SCAT) 
      and muscle (longissimus dorsi [LD]) of butyrate-supplemented piglets. In vitro, 
      butyrate increased (P < 0.05) fatty acid oxidation in primary adipocytes and 
      suppressed basal lipolysis by 62% compared to untreated cells. Butyrate 
      suppressed (P < 0.05) lipogenesis ((14)C-glucose incorporation into lipids) in 
      adipocytes. This was accompanied by an approximately 30% reduction in the mRNA 
      expression of fatty acid synthase (P < 0.05) in butyrate-treated cells vs. 
      controls. Piglets born to sows that were supplemented with 0.3% butyrate during 
      the last trimester of gestation had a 15% higher (P < 0.05) body weight at 12 wk 
      than controls. In summary, butyrate supplementation to gestating sows and piglets 
      enhanced postweaning growth performance, which may be mediated by increased 
      substrate oxidation in butyrate treated animals.
FAU - Lu, H
AU  - Lu H
AD  - Department of Animal Sciences, Purdue University, West Lafayette, IN 47907-2054, 
      USA.
FAU - Su, S
AU  - Su S
FAU - Ajuwon, K M
AU  - Ajuwon KM
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - United States
TA  - J Anim Sci
JT  - Journal of animal science
JID - 8003002
RN  - 0 (Butyrates)
SB  - IM
MH  - Adipose Tissue/*metabolism
MH  - Animal Feed/*analysis
MH  - Animal Nutritional Physiological Phenomena
MH  - Animals
MH  - Butyrates/administration & dosage/*pharmacology
MH  - Diet/veterinary
MH  - Dietary Supplements
MH  - Female
MH  - Gene Expression Regulation/*drug effects
MH  - Male
MH  - Muscle, Skeletal/*metabolism
MH  - Oxidative Stress
MH  - Pregnancy
MH  - Swine/*growth & development/physiology
EDAT- 2013/02/13 06:00
MHDA- 2013/07/31 06:00
CRDT- 2013/02/01 06:00
PHST- 2013/02/01 06:00 [entrez]
PHST- 2013/02/13 06:00 [pubmed]
PHST- 2013/07/31 06:00 [medline]
AID - 90/Supplement_4/430 [pii]
AID - 10.2527/jas.53817 [doi]
PST - ppublish
SO  - J Anim Sci. 2012 Dec;90 Suppl 4:430-2. doi: 10.2527/jas.53817.