PMID- 23368088
OWN - NLM
STAT- MEDLINE
DCOM- 20130521
LR  - 20130318
IS  - 1365-2141 (Electronic)
IS  - 0007-1048 (Linking)
VI  - 161
IP  - 1
DP  - 2013 Apr
TI  - Cytogenetics of extramedullary manifestations in multiple myeloma.
PG  - 87-94
LID - 10.1111/bjh.12223 [doi]
AB  - Extramedullary disease in patients with multiple myeloma is a rare event, 
      occurring mostly in advanced disease or relapse. Outcome is poor and prognostic 
      factors predicting the development of extramedullary disease have not been 
      defined. We investigated cytogenetic alterations of myeloma cells in different 
      extramedullary manifestations by adapting the fluorescence in situ hybridization 
      (FISH) technique in combination with cytoplasmic immunoglobulin staining to study 
      the cytogenetics of plasma cell tumours on paraffin embedded material. Thirty six 
      patients were investigated: 19 with extramedullary disease, 11 with skeletal 
      extramedullary disease and six with solitary extramedullary plasmacytoma. The 
      first two groups showed the following results: del(17p13) 32% vs. 27%, del(13q14) 
      35% vs. 27%, MYC-overrepresentation 28% vs. 18% and t(4;14) 37% vs. 18%. We 
      detected an overall higher incidence of del(17p13) in both groups compared to 
      data from bone marrow samples of multiple myeloma reported to date (range 7-16%). 
      The solitary extramedullary plasmacytomas presented overall less cytogenetic 
      aberrations than the other groups. Most important, three patients with 
      extramedullary disease and one with skeletal extramedullary disease presented 
      different FISH findings in the extramedullary tumour compared to their bone 
      marrow plasma cells. del(17p13), occurring additional in three of four cases, 
      seems a strong marker for extramedullary progression of myeloma.
CI  - (c) 2013 Blackwell Publishing Ltd.
FAU - Billecke, Lisa
AU  - Billecke L
AD  - Department of Oncology, Haematology and Bone Marrow Transplantation with Section 
      Pneumology, Hubertus Wald Cancer Centre, University Medical Centre 
      Hamburg-Eppendorf, Hamburg, Germany.
FAU - Murga Penas, Eva M
AU  - Murga Penas EM
FAU - May, Annette M
AU  - May AM
FAU - Engelhardt, Monika
AU  - Engelhardt M
FAU - Nagler, Arnon
AU  - Nagler A
FAU - Leiba, Merav
AU  - Leiba M
FAU - Schiby, Ginette
AU  - Schiby G
FAU - Kroger, Nicolaus
AU  - Kroger N
FAU - Zustin, Jozef
AU  - Zustin J
FAU - Marx, Andreas
AU  - Marx A
FAU - Matschke, Jakob
AU  - Matschke J
FAU - Tiemann, Markus
AU  - Tiemann M
FAU - Goekkurt, Eray
AU  - Goekkurt E
FAU - Heidtmann, Hans-Heinrich
AU  - Heidtmann HH
FAU - Vettorazzi, Eik
AU  - Vettorazzi E
FAU - Dierlamm, Judith
AU  - Dierlamm J
FAU - Bokemeyer, Carsten
AU  - Bokemeyer C
FAU - Schilling, Georgia
AU  - Schilling G
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20130201
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Chromosome Aberrations
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 17/genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/*genetics/pathology/therapy
MH  - Plasmacytoma/genetics/pathology
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2013/02/02 06:00
MHDA- 2013/05/23 06:00
CRDT- 2013/02/02 06:00
PHST- 2012/10/13 00:00 [received]
PHST- 2012/12/17 00:00 [accepted]
PHST- 2013/02/02 06:00 [entrez]
PHST- 2013/02/02 06:00 [pubmed]
PHST- 2013/05/23 06:00 [medline]
AID - 10.1111/bjh.12223 [doi]
PST - ppublish
SO  - Br J Haematol. 2013 Apr;161(1):87-94. doi: 10.1111/bjh.12223. Epub 2013 Feb 1.