PMID- 23368842
OWN - NLM
STAT- MEDLINE
DCOM- 20131017
LR  - 20181202
IS  - 1467-2995 (Electronic)
IS  - 1467-2987 (Linking)
VI  - 40
IP  - 3
DP  - 2013 May
TI  - The effect of fentanyl on the end-tidal sevoflurane concentration needed to 
      prevent motor movement in dogs.
PG  - 290-6
LID - 10.1111/vaa.12013 [doi]
AB  - OBJECTIVE: The objectives of this study were to determine the effects of fentanyl 
      on the end-tidal concentration of sevoflurane needed to prevent motor movement 
      (MACNM ) in response to noxious stimulation, and to evaluate if acute tolerance 
      develops. STUDY DESIGN: Randomized cross-over experimental study. ANIMALS: Six 
      healthy, adult (2-3 years old), intact male, mixed-breed dogs weighing 16.2 +/- 1.1 
      kg. METHODS: Six dogs were randomly assigned to receive one of three separate 
      treatments over a 3 week period. After baseline sevoflurane MACNM (MACNM-B) 
      determination, fentanyl treatments (T) were administered as a loading dose (Ld) 
      and constant rate infusion (CRI) as follows: T1-Ld of 7.5 mug kg(-1) and CRI at 3 
      mug kg(-1) hour(-1); T2-Ld of 15 mug kg(-1) and CRI at 6.0 mug kg (-1) hour(-1); 
      T3-Ld of 30 mug kg(-1) and CRI at 12 mug kg(-1) hour(-1). The MACNM was defined as 
      the minimum end-tidal sevoflurane concentration preventing motor movement. The 
      first post-treatment MACNM (MACNM-I) determination was initiated 90 minutes after 
      the start of the CRI, and a second MACNM (MACNM - II) determination was initiated 
      3 hours after MACNM-I was established. RESULTS: The overall least square mean 
      MACNM-B for all groups was 2.66%. All treatments decreased (p < 0.05) MACNM, and 
      the decrease from baseline was 22%, 35% and 41% for T1, T2 and T3, respectively. 
      Percentage change in T1 differed (p < 0.05) from T2 and T3; however, T2 did not 
      differ from T3. MACNM-I was not significantly different from MACNM-II within 
      treatments. CONCLUSIONS AND CLINICAL RELEVANCE: Fentanyl doses in the range of 
      3-12 mug kg(-1) hour(-1) significantly decreased the sevoflurane MACNM. Clinically 
      significant tolerance to fentanyl did not occur under the study conditions.
CI  - (c) 2013 The Authors. Veterinary Anaesthesia and Analgesia (c) 2013 Association of 
      Veterinary Anaesthetists and the American College of Veterinary Anesthesia and 
      Analgesia.
FAU - Reilly, Sabrina
AU  - Reilly S
AD  - Department of Small Animal Clinical Sciences, College of Veterinary Medicine, 
      University of Tennessee, Knoxville, TN 37996, USA.
FAU - Seddighi, Reza
AU  - Seddighi R
FAU - Egger, Christine M
AU  - Egger CM
FAU - Rohrbach, Barton W
AU  - Rohrbach BW
FAU - Doherty, Thomas J
AU  - Doherty TJ
FAU - Qu, Wen
AU  - Qu W
FAU - Johnson, James R
AU  - Johnson JR
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20130131
PL  - United States
TA  - Vet Anaesth Analg
JT  - Veterinary anaesthesia and analgesia
JID - 100956422
RN  - 0 (Adjuvants, Anesthesia)
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Methyl Ethers)
RN  - 38LVP0K73A (Sevoflurane)
RN  - UF599785JZ (Fentanyl)
SB  - IM
MH  - Adjuvants, Anesthesia/administration & dosage/*pharmacology
MH  - Anesthetics, Inhalation/administration & dosage/*pharmacology
MH  - Animals
MH  - Cross-Over Studies
MH  - Dogs/*physiology
MH  - Dose-Response Relationship, Drug
MH  - Fentanyl/administration & dosage/*pharmacology
MH  - Male
MH  - Methyl Ethers/administration & dosage/*pharmacology
MH  - Motor Activity/*drug effects
MH  - Sevoflurane
EDAT- 2013/02/02 06:00
MHDA- 2013/10/18 06:00
CRDT- 2013/02/02 06:00
PHST- 2011/07/01 00:00 [received]
PHST- 2012/02/03 00:00 [accepted]
PHST- 2013/02/02 06:00 [entrez]
PHST- 2013/02/02 06:00 [pubmed]
PHST- 2013/10/18 06:00 [medline]
AID - S1467-2987(16)30235-5 [pii]
AID - 10.1111/vaa.12013 [doi]
PST - ppublish
SO  - Vet Anaesth Analg. 2013 May;40(3):290-6. doi: 10.1111/vaa.12013. Epub 2013 Jan 
      31.