PMID- 23368844
OWN - NLM
STAT- MEDLINE
DCOM- 20130909
LR  - 20130313
IS  - 1443-1661 (Electronic)
IS  - 0915-5635 (Linking)
VI  - 25 Suppl 1
DP  - 2013 Mar
TI  - Role of antisecretory agents for gastric endoscopic submucosal dissection.
PG  - 86-93
LID - 10.1111/j.1443-1661.2012.01370.x [doi]
AB  - Gastric endoscopic submucosal dissection (ESD) causes artificial gastric ulcers 
      and there is no consensus regarding the optimal perioperative management in terms 
      of prevention of intra- or postoperative bleeding and promotion of healing. 
      Traditionally, 8-week administration of proton pump inhibitors (PPI) and mucosal 
      protective agents were used in the same way as for peptic ulcer management. 
      However, recent studies have revealed that prior use of PPI might reduce 
      intraoperative bleeding or early-phase postoperative bleeding, and combination of 
      histamine-2 receptor antagonist (H2RA), and second-look endoscopy might have a 
      similar effect on postoperative bleeding to PPI. Additionally, the advantage of 
      PPI over H2RA is not proven and the optimal duration of PPI may be shortened 
      until 2 weeks when the deteriorating factors for ESD ulcer are excluded. 
      Furthermore, mucosal protective agents may facilitate ulcer healing. Further 
      studies are needed to determine the optimal treatment protocol before and after 
      ESD for both prevention of bleeding complication and promotion of ulcer healing, 
      by using available antisecretory agents and mucosal protective agents.
CI  - (c) 2013 The Authors. Digestive Endoscopy (c) 2013 Japan Gastroenterological 
      Endoscopy Society.
FAU - Fujishiro, Mitsuhiro
AU  - Fujishiro M
AD  - Department of Endoscopy and Endoscopic Surgery, Graduate School of Medicine, The 
      University of Tokyo, Tokyo, Japan. mtfujish-kkr@umin.ac.jp
FAU - Chiu, Philip W Y
AU  - Chiu PW
FAU - Wang, Hsui-Po
AU  - Wang HP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
DEP - 20130124
PL  - Australia
TA  - Dig Endosc
JT  - Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy 
      Society
JID - 9101419
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (Proton Pump Inhibitors)
RN  - 54182-58-0 (Sucralfate)
SB  - IM
MH  - Dissection/*methods
MH  - Drug Administration Schedule
MH  - Electrocoagulation
MH  - Follow-Up Studies
MH  - Gastric Mucosa/blood supply/drug effects/pathology/*surgery
MH  - Gastroscopy/*methods
MH  - Histamine H2 Antagonists/*administration & dosage/adverse effects
MH  - Humans
MH  - Japan
MH  - Microvessels/surgery
MH  - Peptic Ulcer Hemorrhage/*prevention & control
MH  - *Perioperative Care
MH  - Postoperative Complications/*prevention & control
MH  - Postoperative Hemorrhage/*prevention & control
MH  - Preoperative Care
MH  - Proton Pump Inhibitors/*administration & dosage/adverse effects
MH  - Reoperation
MH  - Risk Factors
MH  - Stomach Neoplasms/pathology/*surgery
MH  - Stomach Ulcer/*prevention & control
MH  - Sucralfate/administration & dosage
MH  - Surgical Instruments
MH  - Wound Healing/drug effects
EDAT- 2013/02/02 06:00
MHDA- 2013/09/10 06:00
CRDT- 2013/02/02 06:00
PHST- 2012/02/05 00:00 [received]
PHST- 2012/07/18 00:00 [accepted]
PHST- 2013/02/02 06:00 [entrez]
PHST- 2013/02/02 06:00 [pubmed]
PHST- 2013/09/10 06:00 [medline]
AID - 10.1111/j.1443-1661.2012.01370.x [doi]
PST - ppublish
SO  - Dig Endosc. 2013 Mar;25 Suppl 1:86-93. doi: 10.1111/j.1443-1661.2012.01370.x. 
      Epub 2013 Jan 24.